UNSTABLE TRIPLETS, MICROSATELLITES,

Cambridge Symposia symposia at xensei.com
Fri Dec 6 11:07:22 EST 1996


UNSTABLE TRIPLETS, MICROSATELLITES, 
AND HUMAN DISEASE
Organizers:  Jack Griffith, University of North Carolina-Chapel Hill, 
Robert Wells, Texas A&M University, 
and David Nelson, Baylor College of Medicine
April 1-6, 1997; Santa Fe, New Mexico

Tuesday 4/1
2-7pm	Registration
8-9pm	KEYNOTE ADDRESS
	C. Thomas Caskey, Merck & Company
	“Triplet Diseases: Past, Present and Future”

Wednesday 4/2
7-8am	Breakfast
8-11:30am  WELCOME INTRODUCTION:  UNSTABLE MICROSATELLITES:
	   MECHANISMS AT THE DNA LEVEL I
	Jack Griffith, University of North Carolina-Chapel Hill
	“Welcome Introduction”
	Miroslav Radman, Institute Jacques Monod-FRANCE
	“Interplay Between SOS and Mismatch Repair Systems in Genome 
	(in)Stability and Evolution”
	Geoffrey Wahl, Salk Institute for Biological Studies
	“p53 Dependent Cell Cycle Responses to DNA Mismatches 
	Involving p53”
	Richard Fishel, Thomas Jefferson University
	“The Recognition of Mispaired Nucleotides, Microsatellite 
	Sequences and DNA  Lesions by the Human Mismatch Repair 
	System”
	Stephen Thibodeau, Mayo Clinic
	“Microsatellite Instability in Colon Cancer”
	Michael Siciliano, University of Texas/MD Anderson Cancer Center
	“Factors Affecting Microsatellite Instability”

1:30-3:30pm	WORKSHOP: GENOME INSTABILITY AND REPAIR
	        MICROSATELLITE DNA STRUCTURE

7:30-10:30pm	UNSTABLE MICROSATELLITES:  MECHANISMS AT THE DNA 
	        LEVEL II
	Robert Wells, Texas A&M University
	“DNA Structure, Triplet Repeats, and Human Hereditary Diseases”
	Thomas Kunkel, National Institutes of Environmental Health Sciences
	“Studies of Replication Fidelity and Mismatch Repair of Repetitive 
	DNA Sequences”
	Sam Wilson, National Institute of Environmental Health Sciences
	“Where Errors Could Occur at the Level of Replication”
	Tom Petes, University of North Carolina-Chapel Hill
	“Microsatellite Instability in Yeast”

Thursday 4/3
7-8am	Breakfast
8-11:30am   MICROSATELLITE CHROMATIN, TELOMERES, FRAGILE SITES,
	    AND THE FRAGILE X SYNDROME I
	Jack Griffith, University of North Carolina-Chapel Hill
	“Microsatellite Chromatin:  Properties and Pathology”
	Tom Glover, University of Michigan
	“Molecular Delineation of Common Fragile Sites” 
	Titia de Lange, The Rockefeller University
	“Mammalian Telomeric Proteins”
	Virginia Zakian, Princeton University
	“Maintaining Saccharomyces Telomeres”
	Robert Richards, Women’s and Children’s Hospital-AUSTRALIA
	“Molecular Genetics of Fragile Sites”

1:30-3:30pm	WORKSHOP: CHROMOSOME STRUCTURE AND FRAGILE X
	        MYOTONIC DYSTROPHY/FRIEDREICH’S ATAXIA

7:30-10:30pm	MICROSATELLITE CHROMATIN, TELOMERES, FRAGILE SITES,
	        AND THE FRAGILE X SYNDROME II
	David Nelson, Baylor College of Medicine
	“The Fragile X Diseases”
	B. A. Oostra, Erasmus University-NETHERLANDS
	“Fragile X Syndrome and the Gene Involved”
	Stephen Warren, Emory University
	“Molecular Basis of Fragile X Syndrome”
	Walter Doerfler, University of Köln-GERMANY
	“On the Molecular Biology of the Fragile X Syndrome”

Friday 4/4
7-8am	Breakfast
8-11:30am   MYOTONIC DYSTROPHY AND FRIEDREICH’S ATAXIA: LOSS OF
	    FUNCTION MICROSATELLITE DISEASES AND CANCER I
	Robert Korneluk, Childrenís Hospital of Eastern Ontario Research 
	Inst-CANADA
	“Myotonic Dystrophy (DM):  Effect of the CTG Repeat Mutation on 
	Expression of the DM Kinase Gene”
	David Housman, Massachusetts Institute of Technology
	“Myotonic Dystrophy Kinase Gene Expression”
	B. Wieringa, University of Nijmegen-NETHERLANDS
	“The DM Locus in Mouse and Man: Genotype - Phenotype Correlations”
	Keith Johnson, University of Glasgow-UK
	“Is Myotonic Dystrophy a Polygenic Disorder?”
	Eric Hoffman, University of Pittsburgh School of Medicine
	“Myotonic Dystrophy: Evidence for a Dominant-Negative RNA Mutation”

1:30-4:30pm	MYOTONIC DYSTROPHY AND FRIEDREICH’S ATAXIA: LOSS OF
	        FUNCTION MICROSATELLITE DISEASES AND CANCER II
	Massimo Pandolfo, CRLS - Pavillon de Seve-CANADA
	“Friedreich’s Ataxia”
	Carlo Croce, Thomas Jefferson University
	“Genetics of Human Cancer”
	Guillermina Lozano, University of Texas/MD Anderson Cancer Center
	“Cancer Predisposition in Li Fraumeni Syndrome”
	Charles Cantor, Boston University
	“New Approaches to Genome Analysis” 

8-10pm	BANQUET

Saturday 4/5
7-8am	Breakfast
8-11:30am   CAG/POLYGLUTAMINE NEURODEGENERATIVE DISEASES:
	    GAIN OF FUNCTION? I
	Jean-Louis Mandel†, INSERM-University Louis Pasteur-FRANCE
	“Huntington’s Disease and Spinocerebellar Ataxia”
	Kenneth Fischbeck, University of Pennsylvania School of Medicine
	“Kennedy’s Disease”
	Marcy MacDonald, Massachusetts General Hospital
	“Huntington’s Disease”
	Harry Orr, University of Minnesota
	“Repeat Instability and Pathogenesis of SCA1 in Transgenic Mice”
	Gillian Bates†, UMDS-Guy’s Hospital-UK
	“Huntington’s Disease Mouse Model”

1:30-3:30pm	WORKSHOP: POLYGLUTAMINE DISEASES: PATHOLOGY
	        POLYGLUTAMINE DISEASES: PROTEIN STRUCTURE

8-10:30pm    CAG/POLYGLUTAMINE NEURODEGENERATIVE DISEASES:
	     GAIN OF FUNCTION? II
	Akira Kakizuka, Kyoto University-JAPAN
	“Molecular and Genetic Bases of Machado-Joseph Disease”
	Christopher Ross, Johns Hopkins University School of Medicine
	“Huntington’s Disease and DRPLA”
	Jeffrey Vance, Duke University Medical Center 
	“Haw River Syndrome”

Sunday 4/6
	DEPARTURE


How To Register:

Registration Fees will be based on the DATE Received in our office, 
not the date postmarked. All checks must be drawn on a U.S. Bank 
in U.S. Currency.

Abstract ONLY (by January 22, 1997)  
               Poster Abstract Submission Fee: $50
Abstract/Registration 
              (Send Abstract/Registration before January 22, 1997)
	Registration Fee: $475	Student Fee: $350	Commercial: $600
Late or on-site Registration (Register after January 22, 1997)
	Registration Fee: $575	Student Fee: $400	Commercial: $700

Lodging/Fees Information

Santa Fe, New Mexico	Phone: 505-988-2811
Hilton of Santa Fe	Fax: 505-986-6439
100 Sandoval Street
PO Box 25104
Santa Fe, NM 87501

Santa Fe, New Mexico is located approximately one hour north of 
Albuquerque International Airport.  The Hilton of Santa Fe is 
located within a few city blocks of the Santa Fe Market Place.  
All Accommodation types are limited and are assigned in the order 
in which the hotel receives your request and lodging deposit.  
Lodging rates are per conferee and are subject to state and local 
taxes.  The full lodging package is charged regardless of the 
length of stay.  You must identify yourself as a Cambridge Symposia 
conferee to receive these rates.  Full payment for your accommodations

is due and payable to the hotel upon arrival.  Do not send payment for

lodging to the Cambridge Symposia.

The Hilton of Santa Fe: Single or Double: $575.00	
                                      Non-Resident: $90.00
(Rates do not include state and local taxes.)

Unscheduled Late Arrivals at the Hotel:  The Hotel will hold units 
for late arrivals until no later than 8 am on the first full day of 
the conference week.

Non-Resident/Facility Fee: All persons who chose to make lodging 
reservations throug a hotel other than the Hilton of Santa Fe are 
referred to as “Non-Residents” and are required to pay a FACILITY FEE.

The Facility Fee is due and payable to the hotel upon arrival.

PLEASE NOTE: The first day of the conference is registration and 
Keynote Address and the last day is departure day only.

TRAVEL INFORMATION

Exclusive airline discounts are available on specific airlines when
tickets are purchased through Travelworld at least 14 days prior to
the meeting date.  Some restrictions apply.

TRAVELWORLD	Phone: 717-288-9311
601 Market Street	1-800-828-6033
Kingston,  PA  18704	Fax: 717-288-4693


----PLEASE COPY  AND PRINT OUT FROM HERE------------------------

CAMBRIDGE SYMPOSIA REGISTRATION FORM	CS03-97

UNSTABLE TRIPLETS, MICROSATELLITES, AND HUMAN DISEASE

Please send information on:
|__|  AD/Exhibitor Space	|__|Meeting Sponsorship
Please check ONLY ONE box below.
|__|  $50 ABSTRACT FEE ENCLOSED (Abstract Submission only) 
(Make a copy of this form to send in with your abstract, 
if not registering at this time.)
|__| ABSTRACT/REGISTRATION FEE ENCLOSED
|__| REGISTRATION FEE ONLY ENCLOSED
|__| LATE REGISTRATION FEE ENCLOSED

IMPORTANT:  Please Sign and Date
I understand that I am responsible to RESORT for the minimum unit 
rate required for the accommodation to which I am assigned.  If I am 
assigned a private bedroom in a shared unit, or shared accommodations,

and the other individual(s) cancels, I will cooperate in relocating to
another room where I may assume rates and arrangements, I originally 
sought, if possible.  If I choose not to relocate, I will be
responsible to RESORT for the adjusted lodging rates as necessitated 
by the change in occupancy.

Signature:_________________________________Date:___________________________
	
					             
Submitting Abstract/Fee ONLY (BY  1/22/97)	
|__| STUDENTS $50      |__| ACAD/GOV’T  $50          |__| COMMERCIAL  $50
Abstract/Registration (BY  1/22/97)
|__| STUDENTS $350    |__|  ACAD/GOV’T$475         |__| COMMERCIAL$600
On-site or Late Registration (AFTER  1/22/97)
|__| STUDENTS $400    |__|  ACAD/GOV’T $575        |__| COMMERCIAL $700

LAST NAME:_________________________________________________

FIRST NAME:________________________________________________

DEPARTMENT:_______________________________________________

INSTITUTE:__________________________________________________

STREET/P.O. 
BOX:________________________________________________________

CITY/STATE/ZIP:_____________________________________________

COUNTRY:___________________________________________________

PHONE:_________________________FAX:_________________________

E-MAIL:______________________________________________________

Registration is not complete until the registration fee is received.  
Forms arriving without fees will not be accepted.  Payment of the 
registration fee entitles you to receipt of the abstract book, 
admittance to all sessions, food functions, coffee breaks and the 
banquet.

|__| Enclosed is a my check or money order payable to Cambridge Symposia.

|__| Enclosed is a my credit card.

|__| Enclosed is my purchase order.

ABSTRACT PAYMENT DUE:
	$50 Abstract Submission Fee (if submitting ABSTRACT ONLY):$___________

REGISTRATIONPAYMENT DUE:

|__| Check here if you PREVIOUSLY submitted an Abstract and the $50 Abstract 
     Submission Fee.

If you previously submitted an Abstract and the Abstract Submission 
Fee, subtract $50 from the applicable registration fee.  The Poster 
Abstract Submission Fee must be paid by each FIRST Author.  Payment 
must be drawn on a U.S. Bank in U.S. Currency and must be received by 
the abstract deadline.  Co-authors MAY NOT deduct the Poster Abstract 
Submission Fee.  The Poster Abstract Submission Fee is applied to the
cost of your Registration Fee, therefore, abstract submission does not

increase the cost of conference attendance.  The registration fee is a

conference fee and is not deducted from your confirmed accommodations 
package.

Registration Fee:		     $__________

Late or On-Site Registration Fee:	     $__________

Subtract Abstract Submission Fee (if previously submitted): 
                                                          $__________

                                   TOTAL DUE:  $__________

Type of Card: 
      
 |__|  AmEx  |__|  VISA  |__|  MasterCard  |__|  Eurocard

Name EXACTLY As it Appears On 
Card:_____________________________________________

ACCOUNT NUMBER:	
_________________________________________________
 (AmEx = 15 digits;  VISA = 13 or 16 digits;  MasterCard & Eurocard =
16 digits)

Credit Card Expiration Date:____________

Cardholder's Signature:_____________________________________________

I authorize the Cambridge Symposia to charge my credit card for the 
total fees listed above.

HANDICAPPED EQUAL ACCESS:  In accordance with the ADA, Cambridge 
Symposia is pleased to arrange for special accommodations for 
attendees with special needs.  All requests for such assistance must 
be submitted to Cambridge Symposia in writing at least 30 days prior 
to the start of the conference.

MAIL THIS REGISTRATION FORM TO:  
Cambridge Symposia, 1037 Chestnut Street, Newton Upper Falls, MA 02164
Phone:  617-630-1399  •  Telefax: 617-630-1395  •  E-mail:
symposia at cambridge.org
Send Abstracts by E-mail to: ahandy at cambridge.org 
(When sending abstracts by e-mail, please send two good quality 
copies of your abstract and this form to our office.)
http://www.cambridge.org/symposia/ 
(If you would like to link your web page to ours please 
contact our office)




More information about the Neur-sci mailing list