Rate of diffusion in brain

Matt Fraser mof at prophet.pharm.pitt.edu
Mon Dec 9 20:26:09 EST 1996


On 4 Dec 1996, William Barnes wrote:

> Hello,
> 	I have been infusing solid drugs into the brain and have been having a
> hard time controlling the rate of diffusion of the drug through brain
> tissue.  Does anyone have any comments to offer in this regard?  Thanks.
> 			William Barnes

What do you mean "infusing solid drugs"?  If you are depositing pellets,
there are a variety of binders that may be helpful to slow diffusion.
It's important to consider the solubility properties of the drugs - are
they lipophilic?  Is there any way to covalently bind them to larger
molecules without altering their effects? By controllin, do you mean
that there is a lot of variability, or you'd prefer them to act only
locally?  Are co-administering an inert marker with like solubility that
might allow you to "guestimate" the areas of diffusion? Would looking at
shorter exposure times help?

Just some thoughts,

Matt

  _______________________________________________________

Matt Fraser                        "Hey, You! Don't help them 
                                       To bury the Light.
mof at prophet.pharm.pitt.edu               Don't give in
mattf+ at pitt.edu                         Without a Fight."

                                           Pink Floyd




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