CARDIAC OUTPUT MEASUREMENT IN RATS & MICE

PradipG pradipg at aol.com
Wed Dec 18 12:10:33 EST 1996


BLOOD PRESSURE & CARDIAC OUTPUT MEASUREMENT IN MICE & RATS

During the last decade, the production of transgenic mice, with different
gene expression provided a valuable tool for the study of genes involved
in cardiovascular functions in 
recipient. In small animal, the hemodynamic measurement is very limited
because of the animal size. The most important and basic cardiovascular
parameters, considered by physiologists and pharmacologists, are cardiac
output, blood pressure, heart rate and stroke volume. Despite the plethora
of instruments currently available for studying the above mentioned
parameters in laboratory animals, no such instrument can measure all four
parameters simultaneously except CARDIOMAX-IIR. Thermodilution technique
in measuring cardiac output is most frequently used in human and in
different animals. A little information is available in measuring cardiac
output in mice. Recently, we have 
established the measurement of cardiac output in mice by thermodilution
technique using CARDIOMAX-IIR. We injected a bolus of 15 ul of saline
(room temp.) through jugular vein to the vena cava and the resultant
change in temperature was measured in the arch of aorta. We found that
cardiac output in mice ranges between 10 and 12 ml/min. If you are
interested in receiving more information, please provide your street
address, I will mail you all information.

DR. GHOSH
PHYSIOLOGIST




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