GHB,TIANEPTINE and ANTIDEPRESSANTS

Keneth Grandchamp grandcha at cmu.unige.ch
Thu Jan 4 09:33:49 EST 1996




GAMMA-OH(Gamma-Hydroxybutyrate):The First Authentic Anti-Depressant (4)
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As I do not have much time to answer,individually,all questions received 
concerning Gamma-OH, you will find here more information about this 
molecule.New information has been added,regularly,in this article so as to 
answer to your questions.
Introduction
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Recently,the whole world was brainwashed by Lilly Company with a severe 
blitzkrieg propaganda on an allegedly "new" anti-depressant called fluoxetine 
or Prozac.Lilly lied when it presented Prozac as being the "first" marketed 
anti-depressant of a "new" generation!The first marketed anti-depressant of 
this new family of anti-depressants called the "SSRI" was ZIMELIDINE marketed 
by Astra,in Europe,as Normud,and developped in Scandinavia.Zimelidine was 
followed by INDALPINE in France(Upstène)and then by FLU
VOXAMINE in Holland(Floxyfral).
Only FLUVOXAMINE withstood the test of time as zimelidine and indalpine had 
some unwanted side-effects,even though indalpine proved to be a remarkable 
molecule for some treatment resistant persons.Fluvoxamine was marketed in 
Europe perhaps 8 YEARS BEFORE its american equivalent Prozac!Even though it 
did not reach the US market because American pharmaceutical companies could 
not yet compete with Europeans...So Fluvoxamine was blocked to reach the US 
market until Americans could develop properly their own 
SSRI! This is what american businessmen,usually,call "fairplay".By doing 
so,millions of Americans did not benefit of Fluvoxamine and,surely,many lives 
could had been saved in America by Fluvoxamine....Alas,these lives WERE NOT 
saved because of the greed and unfair practices of the american system towards 
novel medications invented elsewhere.Millions of depressed Americans were 
denied access to Fluvoxamine, for commercial purposes only.This is a moral 
perversion of the ethic of medicine.
The sad irony of this situation is that Fluvoxamine is superior ,in all 
respects,to Prozac!
For instance,Prozac has some unwanted side-effects which fluvoxamine does not 
have.Moreover,fluvoxamine can SUPPRESS the side-effects of Prozac! So why use 
Prozac at all? This is due to the fact that Lilly was very successful in 
launching a blitzkrieg propaganda campaign,superbly ignoring our european 
product and its anteriority.Moreover,the idea of developping a specific 
serotonin reuptake blocker was a european idea and not an american idea as 
Americans did not believe in the anti-depressant effects of
 serotonin but favoured noradrenaline...
Prozac,frequently,induces insomnia and headaches while it is also slighly 
sub-hallucinogenic.Fluvoxamine,on the contrary,promotes sleep and alleviates 
headaches.Also no subhallucinogenic phenomena can be detected.One reason why 
Prozac has these side-effects is because Prozac 
should,preferentially,indirectly activate serotonin 5-HT2A 
receptors.Activation of these receptors is a common effect of the 
hallucinogens.
All the unwanted side-effects of,let say a dose of 4O mgr of Prozac are 
abolished by an equipotent dose of IOO mgr of fluvoxamine.
Fluvoxamine also suppresses rapidly moral suffering(the hard-core of 
depression)and suicidal ideation while Prozac is slower on onset.
So the big commercial problem for american companies was that fluvoxamine was 
invented not in America but in Europe and marketed about 8 years before they 
could SELL their own similar products....Moral perversion,as I said,and 
totally unacceptable.
No comments!
Another good european anti-depressant of which Americans have no equivalent is 
AMINEPTINE(Survector)and,naturally,Amineptine is not marketed in the USA even 
though it is a dopaminergic anti-depressant and dopaminergic anti-depressants 
are known to be more effective in treatment resistant patients.Why Americans 
have not yet marketed dopaminergic anti-depressants remains an enigma.As 
Japanese say:"kaouaï so" for american patients,meaning american patients are 
most unfortunate(because money always comes bef
ore morality in the US).In fact,the activation of dopamine seems more crucial 
in order to obtain a fast anti-depressant effect than modulation of other 
neurotransmitters as the function of dopamine in the CNS is to metabolically 
activate neuronal systems.Dopamine is an ubiquitous metabolic activator while 
serotonin has,most frequently,the opposite action(this is called the 
Dopamine/Serotonin balance hypothesis;there is also a Serotonin/Serotonin 
balance hypothesis.This hypothesis states that the global m
etabolic action of serotonin is the ratio of activation of  serotonin 
receptors diminishing dopaminergic activity to those serotoninergic receptors 
which increase dopamine activity,such as the 5-HT2A receptors).Concerning 
novel anti-depressants the French have invented the very first Selective 
Serotonin reuptake Accelerator(SSRA):Tianeptine.Tianeptine acts in an opposite 
way as the SSRI but,still,instead of inducing depressions cure depressions! In 
the naive understanding of serotonin in depression such 
a fact cannot be understood...We will explain later on why tianeptine is,in 
fact,an anti-depressant and even the FIRST authentic serotoninergic 
anti-depressant!
So we are left with the morally unacceptable fact that America has banned 
superior european anti-depressants because the same equivalent products did 
not yet exist in America.
This behaviour of the american pharmaceutical companies has been 
systematic.For instance a good anti-depressant invented in Italy and called 
TRAZODONE was,recently, imitated in America with the creation of 
NEFAZODONE(Serzone)in order to get more money! And another novel 
anti-depressant invented in Europe,VILOXAZINE(the first selective 
noradrenaline reuptake inhibitor),apparently never reached the US 
market,etc,etc.
Now I will come to a fantastic anti-depressant called GAMMA-OH(brand name),and 
which 
could save lots of depressed people if it were marketed to that effect.
GAMMA-OH has never been studied as an anti-depressant because of what is 
called the 
IMIPRAMINOMIMETIC DOGMA .This dogma states that anti-depressants can only be 
found by those pharmacological methods which have been applied to discover 
imipramine,the first alleged anti-depressant!Clearly,this dogma is nonsense 
and it has hampered research on anti-depressants since more than 30 
years,forbidding the discovery of true fast-acting anti-depressants.This dogma 
also states that it is not possible to achieve an anti-depressant effect 
immediately but that one has to suffer for weeks before start
ing to feel better with medication...What is funny with this grotesque dogma 
is that imipramine was discovered by chance!At that time nobody believed in 
imipramine except one lone researcher whose obstinate perserverance was 
rewarded...
GAMMA-OH(or gamma-hydroxybutyrate,a quite simple molecule with a vast array of 
psychotropic properties)has proved that this statement was sheer nonsense. 
GAMMA-OH was discovered by a friend of mine(the late Dr.Henri Laborit who 
introduced the use of chlorpromazine in psychiatry around I952)in I96I in 
France and since that time scientists were unable to discover some rather 
extraordinary properties of this molecule on depression,anxiety and 
sociability! Why? Because nobody seriously studied the psychotropic effects of 
this molecule until I started to do the job.This stems from the fact that most 
"scientists" are not real scientists or savants but only civi
l servants:they work to earn their food,not to really discover nature's 
mysteries.These civil servants(called "fonctionnaires",in French,a simpler 
word) work like soldiers in an Army,not like true researchers because they are 
not authentic researchers!They have ideas and interests of "fonctionnaires" 
not of savants...For some years GAMMA-OH was used as an hypnotic in France but 
people complained that they did not sleep long enough with that and would 
awake too early in the morning!Then,according to Henri
 Laborit,came May I968 and Gamma-OH was considered subversive:it thus became a 
medicine only available on prescription.And of course a medicine which can 
enhance sociability is,indeed,subversive because sociability does not go well 
along with business and merchants!To be a good merchant you 
need,psychologically,to block your sociable feelings:you should cease to 
consider other human beings as human beings but just as things which can bring 
you money and power.You have to learn to be selfish,that is non-s
ociable!
GAMMA-OH is a remarkable molecule because it can suppress depressive ideation 
and anxiety sometimes within less than 3O minutes.It also seems to be 
immediately active on the most severe and treatment resistant forms of 
depression.Because of such remarkable properties I used to 
call,jokingly,GAMMA-OH "Or Potable",in French,which means "potable gold"! 
Indeed a molecule which can block your depression and suicidal 
ideas,anxiety,etc,in such an efficient way is as precious as gold because it 
can save your lif
e.
GAMMA-OH saved my own life many times when all other anti-depressants 
failed.For years I suffered of depressive episodes which did not react to 
conventional "anti-depressants".Why? Because,in fact,most anti-depressants(an 
anti-depressant is also called a THYMOANALEPTIC.A thymoanaleptic is a molecule 
which stimulates mood)are not really "anti-depressants" per se but 
THYMOANESTHESISERS.A thymoanesthesiser is a molecule which ANESTHESISES 
emotions and which,thus,blunt feelings.For instance,if you give "anti
-depressants" to,let say,two lovers together you will notice that their love 
feelings towards one another become anesthesised,blunted...Clearly,a molecule 
which blunts rewarding emotions is definitely not an authentic anti-depressant 
but,rather,a "mind Xylocaine"(xylocaine is an anesthesiser used for hemorhoids 
and all kinds of similar pains!).A thymoanesthesiser takes away a part of your 
personality and makes you a bit similar to people suffering from negative 
schizophrenia.On the contrary if you admini
ster gamma-hydroxybutyrate to a pair of lovers you will notice that it will 
enhance their love feelings because it stimulates sociability.
Prozac and Fluvoxamine and all SSRI are,in fact,thymoanesthesisers not 
authentic thymoanaleptics.They block depression by SUPPRESSING or reducing 
feelings,euphoric or dysphoric and you become a kind of satisfied zombie! 
Another thymoanesthesiser,which is not a SSRI,and which blocks quite 
spectacularly love feelings is MAPROTILINE,a slightly modified tricyclic.In my 
opinion,maprotiline is psychotoxic because it can induce indifference in 
otherwise normal subjects.No more suffering but no more real happine
ss.On the contrary,AMINEPTINE does not suppress emotions but it does not 
intensify them either.So amineptine is an anti-depressant but still not the 
ideal thymoanaleptic.Now we can come back to tianeptine.Why tianeptine is an 
anti-depressant?We have seen that serotoninergics alleviate depression by 
reducing emotions.Enhancing serotonin neurotransmission,in fact,anesthesises 
emotions.Thus it is logical that reducing serotonin neurotransmission( in some 
unknown brain areas )should stimulate the expression 
of emotions.This is demonstrated by tianeptine and by some tryptophane 
hydroxylase inhibitors such as MDA or MDMA.What is more interesting is that 
even though MDMA selectively destroys the axons of the raphé nucleus the 
behavioural consequences of that are,apparently,non-existent.Further reducing 
serotonin neurotransmission in MDMA subjects having a depressive episode,with 
tianeptine,can suppress depression in these people! One person who had taken 
MDMA at high doses for 5 years and who became depressed 
reported that,under tianeptine,he would feel like under MDMA!!! Of course no 
normal patient has ever reported an MDMA-like effect with tianeptine...As 
tianeptine activates emotions instead of reducing them TIANEPTINE CAN THUS BE 
CONSIDERED AS THE FIRST AUTHENTIC SEROTONINERGIC ANTI-DEPRESSANT.But who knows 
tianeptine in North-America? Nearly nobody because the French are very,very 
bad businessmen not like those of Lilly! French can invent good novel products 
but are not good at propaganda.Lilly invented 
a mediocre product but persuaded everybody that their product was the best 
ever...If the French had been so clever as Lilly,Amineptine,for instance,would 
have invaded the whole world years and years ago,not to speak about 
tianeptine! The French have invented many novel anti-depressant but did 
practically nothing to spread them.Some of these 
are:médifoxamine(Clédial),minaprine(Cantor),Viloxazine(Vivalan),not to speak 
about amineptine and tianeptine! What's more they invented(by chance!)Gamma-OH 
and never 
discovered that this was a very novel anti-depressant! Knowledgeable people 
just used Gamma-OH like Champagne or Beaujolais but did nothing 
more...Gamma-OH stayed for the elite and the elite was not interested to study 
the peculiar psychotropic effects of this molecule! 
After years of reflexions on depression I realised,one day,that a real 
anti-depressant should STIMULATE SOCIABILITY.Why? Because depression 
is,basically,a defect of sociability.Depression is a state of LOWERED 
SOCIABILITY and when natural sociability is lowered in a human brain(for 
instance through competition,etc)then this brain starts to suffer 
morally.Experience has shown that when sociability is ENHANCED then depression 
vanishes.GAMMA-OH is the first molecule discovered which does just this:it 
STIMUL
ATES SOCIABILITY.This is why GAMMA-OH is called a SOCIABILISER.
GAMMA-OH is hypothesised to cure depression by stimulation of brain OXYTOCIN 
neurotransmission.Oxytocin is a very important molecule responsible of 
sociable states,of the maternal instinct and of all activities related to the 
maintainance of life.For instance,oxytocin is involved in sex and orgasm and 
orgasm intensity seems directly linked to enhanced oxytocin neurotransmission.
GAMMA-OH suppresses depressed ideation with amazing rapidity.You may feel 
uncurable dysphoria with suicidal ideation,anxiety,etc,and think that no 
medicine or no one could help you until you try gamma-hydroxybutyrate! After 
you may just think how crazy you were and feel how life is beautiful and 
deserves to be lived and enjoyed!
Gamma-hydroxybutyrate strongly stimulates the desire to be and to remain alive 
despite unfavourable circumstances.No conventional so-called anti-depressant 
does that.
Gamma-OH is the fastest anti-depressant known and can,often,suppress severe 
depressive ideation within just hours while conventional thymoanesthesisers 
take WEEKS or MONTHS to alleviate suffering...GAMMA-OH therapy is also very 
short:less than a month of treatment is effective,as opposed of months or 
years of treatment with other treatments.

How to use Gamma-OH
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GAMMA-OH(this is the brand name of this molecule in France,as I said 
before)should be used as follows:
Three doses of 2 gr per day on an empty stomach.For instance,2gr in the 
morning,then 2gr before eating your first meal,at noon,then the last dose at 
around 6 in the evening.
GAMMA-OH should always be associated with CLONAZEPAM(Rivotril)Imgr taken in 
the morning.If you suffer from intractable moral pain you will be surprised to 
feel that your blocked gratifying emotions come back very,very fast!
GAMMA-OH is a self-limiting medicine,which means that you discover by yourself 
when it is time to stop medication.Why? Because GAMMA-OH induces EMOTIONAL 
SATIETY and when you are emotionally satiated you do not feel like asking for 
more joy as you feel already fed up with happiness!!! Yes,you can be fed up 
with happiness!This is why people using GAMMA-OH do not become addicted.In 
fact,GAMMA-OH is even used to treat alcohol and opiate addicts.
GAMMA-OH gives you a strong DESIRE TO LIVE whatever are the circumstances.This 
is why it is the only authentic anti-depressant 
available.Gamma-hydroxybutyrate was the first sociabiliser which I discovered 
through Henri Laborit.Laborit is well-known in France for his many books on 
society.He used to drink GAMMA-OH 3 times a week,which maintained him in an 
amazing shape! However,Gamma-OH,normally,cannot be taken for a long period of 
time continuously as it tends to induce fatigue and,sometimes,anxiety.So e
motional satiety or fatigue,etc,make Gamma-OH a non-addictive medicine as 
people will,spontaneously,stop medication when they feel these phenomena!
GAMMA-OH is a so-called Gaba B agonist and a TYROSINE HYDROXYLASE ACTIVATOR.
At pharmacological doses,it has,recently,been found,in Strasbourg(France),to 
be a tryptophan hydroxylase activator.At the normal doses used for depression 
and anxiety Gamma-OH has a small regulatory dopaminergic activity:it 
regularises dopaminergic activity.Gamma-OH is found,naturally,in the brain 
together with another more rigid analog called 
GAMMA-HYDROXY-TRANS-CROTONATE(G.H.T.C).GHTC is a close analogue of 
GAMA-AMINO-TRANS-CROTONATE(G.A.T.C) which is one of the most potent agonist of 
the newly discove
red Gaba C receptors.It is not known yet whether Gamma-OH or GHTC bind to 
these Gaba C receptors.There are specific receptors to 4-OHB(another name of 
Gamma-OH!)and GHTC in the brain.These receptors are called GHB 
receptors.French scientists have found that some benzamide neuroleptics bind 
with high affinity to these receptors.Nobody knows yet what 4-OHB and GHTC 
do,exactly,in the brain! They may serve as neuromodulators.The only rather 
clear thing we know is that stimulation of these receptors could be 
involved in the generation of "petit mal" epilepsy.Gamma-OH can induce,very 
rarely(and this is not dose-dependent!)slight subjective effects reminiscent 
of petit mal epilepsy.These effects are adequately blocked by CLONAZEPAM and 
this is the reason why Gamma-OH should,always,better be absorbed with 
clonazepam or other benzodiazepines.Benzodiazepines seem to have a good 
protective effects against the eventual minor side-effects of Gamma-OH.For 
instance,short term use of Gamma-OH is strongly anxiolytic and
 a very effective medication for panic attacks which are reversed within I5 to 
2O minutes(on an empty stomach only).However,if Gamma-OH is taken for weeks it 
can induce what looks like a "rebound" anxiety phenomenon.This anxiety 
manifests itself as plain anxiety or a panic attack just when the psychotropic 
effects of Gamma-OH start to wane.In such cases of 
anxiety,clonazepam(2mgr),midazolam(I5mgr), triazolam(O.5mgr) or 
chlorazépate(Tranxène,25 mgr)should be used.Gamma-OH invariably induces 
vomiting in pe
ople chronically intoxicated with alcohol or people having liver problems.In 
fact,Gamma-OH can be used as a test of liver functioning! However,as Gamma-OH 
stimulates dopamine activity it can give rise to nausea and vomiting with very 
slight increases in the normal dose range which should NEVER exceed 2.5gr 
within 6 hours.Italians have used Gamma-OH ,to treat alcoholics and opiates 
addicts, without serious side effects.They have been using shorter time 
interval than what I recommend and big daily doses wi
th heroin addicts with no apparent serious side-effects.This is in 
contradiction with what Americans have reported...So is there,now,an American 
and a European science??? Why Gamma-OH side-effects are "serious" in 
North-America and "neglegible" in Europe(Italy)? Are these differences of 
opinions related to science OR culture???My opinion is that demonisation of so 
and so is strongly entranched in North-American culture.In North-America 
things have to be good OR bad,black OR white.Something cannot be good
 and bad at the same time,out there...This is an ayatollah way of thinking:it 
is cultural Inquisition.We are more realistic and pragmatic in Europe.Even 
water can lead to intoxication if taken in sufficient amount...Words can also 
intoxicate but words are far more potent than molecules! Adolf Hitler could 
intoxicate and make millions of people hallucinate just with a few words...The 
words of Hitler were hallucinogenic and far,far more potent than 
lysergamide(LSD)! Hitler was a potential emotionnal halluc
inogen,like some mushrooms are potential hallucinogens.But this is a 
philosophical discussion which does not have its place here! Just good to know 
because some north-american "scientists" are also hallucinogenic and spread 
hallucinations...The whole north-american system is strongly hallucinogenic 
with its insidious commercial and puritanical flavour.This is another 
debate...Concerning hallucinogens,Shulgin(a famous scientist)speculated once 
that 5-Methoxy-DMT (a hallucinogen!)might lift rapidly depress
ive ideation.Hallucinogens have not been experimented as anti-depressants yet 
but some facts suggest that some might have an action.This remains to be 
determined.
Many years ago I discovered a second class of Sociabilisers(though less potent 
because of a mixed pro-serotoninergic action)called the TRYPTOPHAN HYDROXYLASE 
INHIBITORS,such as MDMA(3,4 methylenedioxymethylphenylisopropylamine)or 
MDAI(5,6 methylenedioxyaminoindane).The sociabilising actions per se of MDMA 
are similar but GAMMA-OH is more potent and perfectly safe while MDMA is 
neurotoxic and cardiotoxic.MDAI is a non-neurotoxic analogue of MDMA.New 
analogues of both GAMMA-OH and MDMA have been invented b
ut not yet tested.
The sociabilising action of MDMA is related to its indirect blocking of 
SEROTONIN neurotransmission in a brain structure called the MEDIAN RAPHE 
NUCLEUS.When the Median Raphe Nucleus is inactivated then 
sociability,spontaneously,appears.In fact,both GAMMA-OH and MDMA could act at 
a common site modulating oxytocinergic neurotransmission.I have now a 
hypothesis which could link the effects on sociability of these two 
molecules.Basically this hypothesis states that MDMA might be an indirect 
tyrosine hydroxy
lase activator by suppressing the action of serotonin at post-synaptic 5-HT-IA 
heteroreceptors,thus enhancing the activity of tyrosine hydroxylase in some 
unidentified locus.There exists one molecule, called NAN-I9O ,which could help 
in evaluating this hypothesis.GAMMA-OH is a pure sociabiliser while MDMA and 
MDMA-mimetics are partial sociabilisers.At low doses of MDMA the sociabilising 
action of this substance is masked by a pro-serotoninergic action as MDMA 
is,also, a serotonin releaser.This effect of 
MDMA produces a psychotropic action similar to the serotoninergic 
thymoanesthesisers such as fluvoxamine,citalopram,sertraline,etc.At higher 
dosage the sociabilising action of MDMA becomes manifest.Subjectively speaking 
2.5gr of GAMMA-OH are equivalent to 2OOmgr of MDMA.Haloperidol Imgr does not 
block the sociabilising actions of Gamma-OH while it blocks the dopaminergic 
effects of a dose of 2OOmgr of Amineptine,a dopamine re-uptake 
blocker.Haloperidol might block the sociabilising effects of MDMA.This i
s not clear yet.
GAMMA-OH might,theoretically,be also effective against the negative symptoms 
of schizophrenia but this remains to be tested.
GAMMA-OH can be obtained in France under this name.It has been produced since 
its discovery by the Laboratoire Egic,Amilly,France(telephone:30-67-I6-I6).Now 
it is,apparently,produced by another company and this company does not know 
yet that they have potential gold in their hands because if Gamma-OH is 
demonstrated to be the superior anti-depressant which I claim,then it would 
throw in the garbage can most of the antique anti-depressants!You get Gamma-OH 
in vials of 2.5gr to be dissolved in orange juice
 or milk(Henri Laborit's advice!),as its taste is not good.Gamma-OH boxes are 
blue in colour and contain only 6 vials.A box costs about IO swiss 
francs.Gamma-OH is,sometimes,very effective against migraines but only for one 
hour and a half! The activity of Gamma-OH against migraines is not 
predictable,like many other medicines used for that.MDMA is also very 
effective against migraines but this has not been studied...
GAMMA-OH should never be mixed with alcohol,opiates,antibiotics, or anything 
else except benzodiazepines, Amineptine, or Fluvoxamine.The psychotropic 
effects of IOOmgr of fluvoxamine will be suppressed,for about one hour and a 
half,by a dose of 2.5gr of Gamma-OH.Amineptine does not seem to modify the 
psychotropic effects of Gamma-OH while L-Dopa intensifies the hypnotic effects 
of this molecule.
The recommended dose of Gamma-OH should NOT be exceeded.If you overdose,you 
fall into a hypnotic sleep from which you cannot be awaken for 
hours.Moreover,it could promote "petit mal" epilepsy in such overdoses,plus 
nausea and vomiting.Vomiting is a clear sign of relative over-dosage of 
Gamma-OH and is related,apparently,both to the dopaminergic activity of this 
molecule and to liver function.Anyhow there is no need for overdosing.If used 
as prescribed here it is a very safe anti-depressant and anti-panic
 medication.
GAMMA-OH is available only on prescription.I advise those people who see 
everything in term of white or black to consider the considerable benefits for 
suffering people that Gamma-OH could bring if it is demonstrated to be the 
superior anti-depressant which I claim here.Afterwards,more research will,very 
certainly,lead to refined versions of Gamma-OH with minimal side-effects.


The demonisation of Gamma-OH in North-America:A New Form of Inquisition
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We are living since the, I96O's,in a world of INQUISITION against all 
psychotropic molecules  which generate some forms of pleasure.This modern 
Inquisition started in  America as a puritanical expression of american 
society to ban pleasure from life.This Inquisition should be fought against as 
it has halted the development of scientific research on the mind.3O years of 
research have been lost because Americans imposed an INTELLECTUAL EMBARGO on 
many research involving the mind.For instance, all research 
on the hallucinogens was stopped,thanks to this perverse Inquisition.This 
intellectual embargo should be lifted and scientists and laymen should fight 
for that.
No Inquisition can be accepted in the scientific field.American society has 
systematically demonised all psychotropic molecules which can give 
pleasure.(Even alcohol was demonised but this demonisation was not successful 
and was abandonned when it was noticed that the creation of Al Capone and 
other similar people was a consequence of this demonisation!)This is sheer 
madness and should strongly be opposed.The right to use our brain in the way 
we want should be a FUNDAMENTAL RIGHT OF MAN and put in the De
claration of Human Rights.I hope this goal will be achieved in the future.One 
of the reason which motivated me to write what you are reading is that 
GAMMA-OH has been in use,for knowledgeable people in Europe,for decades.Now it 
reached the USA,unfortunately,because,as usual,some american INQUISITORS are 
trying to demonise this very useful molecule.These pseudo-scientific 
AYATOLLAHS should be put back in their middle-ages churchs.In Iran,ayatollahs 
are condemning sex.In America,the american ayatollahs wan
t,desperately,to control the use of our mind.This is an untolerable 
situation.Progress is made through freedom and knowledge,not under the 
guidance of any ayattolah.Let us make a grassroot movement against all these 
ayatollahs! Ayatollahs and similar Inquisitors should go back into their 
dungeons!!! Middle-Age is over.The quest for Freedom is a never-ending 
quest.It is surprising that you do not need,yet,a prescription for 
Champagne,wines and other alcohols in North-America because if alcohol were 
judged
 by pharmaceutical standards it would have been banned a long time ago...

Gamma-OH in France and North-America
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Gamma-oh was invented by Dr.Wermuth,in France,for Dr.Henri Laborit who is the 
father of chlorpromazine and modern psychopharmacology.Wermuth created 
gamma-hydroxybutyrate in I96I in the search of a GABA analog which 
could,readily,penetrate the blood-brain barrier.
Gamma-OH soon went to the market as an hypnotic which could be obtained with 
no medical prescription.The French,until I started to study this molecule,were 
unable to classify it under any class.For sometimes,it was an hypnotic 
inducing a form of sleep very similar to normal sleep,then it became a 
pre-anesthesiser,etc.About I5 years ago,I,finally,discovered that Gamma-OH 
was,in fact,a molecule to be classified under the novel class of the 
Sociabilisers,together with its butyrolactone form which is,readily
,transformed into Gamma-OH in the blood by a non specific lactonase.In 
fact,butyrolactone is a pro-drug giving rise to gamma-hydroxybutyric 
acid.Gamma-OH has a recognised peripheric oxytocinergic action while its 
central oxytocin properties are still to be demonstrated but seem very likely.
Gamma-OH is known in France through the many books of Henri Laborit and his 
conferences!
Laborit always praised the properties of Gamma-OH and,as France is definitely 
not a puritanical society banning pleasure from existence,Gamma-OH has always 
been available,even though its stimulates pleasure.Laborit always advocated 
the general use of Gamma-OH in society,like butter or milk! Why? Because it 
takes away your stress,makes you more positive towards life,suppresses 
selectively,like a kind of "psychological diode",your painful 
feelings,stimulates your sociability and makes you more tender,more 
loving,more concerned by others.Also you become keenly aware that you have 
only one life and that life should be a quest for happiness.Gamma-OH makes you 
realise how much you need others(not something for businessmen and militaries 
or gangsters!!!) and this is a highly positive thing.I always knew that when 
Gamma-OH would arrive in puritanical North-America it would,one day,be 
demonised...Unfortunately for North-Americans,the ayatollahs of the pleasure 
INQUISITION have struck again and banned gamma-hydro
xybutyrate!Laborit just died,recently,a few months ago at an old 
age.Sometimes,he used to joke that Gamma-OH made him live longer as he would 
suppress his stress with this "drinkable gold",in case of need!!! He always 
said that his two greatest discoveries were chlorpromazine and Gamma-OH but he 
never fully realised that Gamma-OH could open a new era in the management of 
depression and anxiety.He never fought in order to promote the study of the 
psychotropic effects of Gamma-OH,he never discovered that G
amma-OH was the first molecule of a novel class:the Sociabilisers.He just 
enjoyed Gamma-OH,with his friends,while conducting other researches.All the 
people who have surrounded Laborit have,naturally,more or less been exposed to 
Gamma-OH! I was lucky to be one of these people.Gamma-OH is still a crude 
medicine.It should be properly studied and better analogs should be 
invented.The use of sociabilisers may have tremendous effects on our 
societies,reducing intra-specific aggression and enhancing cooperatio
n instead of competition.Gamma-OH is a convivial medicine as it shows you that 
you need others to be happy.Long term on and off use seems to make you more 
immune to stress and dysphoria,more loving towards people in general,more 
active in your life as it stimulates your enthusiasm because you are so aware 
that life can be a fantastic thing,everyday.The general use of sociabilisers 
may be a temporary solution for the intra-specific aggressivity of the human 
kind.


When Gamma-OH is contraindicated?
------------------------------------------------------
Untreated epilepsy,eclampsia,hypokalemia,severe 
hypertension,alcoholism,association with opiates,antibiotics.
For depressed patients,Gamma-OH should be taken only under the supervision of 
a medical Doctor.

Claude Rifat,Biologist(with Ken Grandchamp account)



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