Immunology of Sexuality and Variations

Teresa Binstock binstoct at
Tue Jan 23 16:35:00 EST 1996



For the last several months I've been delving into immunology, prompted 
by a realization that nasal perception of other organisms may be due to 
more than via olfactory or vomeronasal receptors. An additional component 
may be nasal epithelia in other than Olf and VNO locales. The means by which 
these non-Olf and non-VNO perceptions might occur may well be 
immunological. Such mechanisms could contribute to why humans can, via 
smelling of urine, determine differences in X and Y chromosomes and also in
variations of autosomal structure. 

Immunological perceptions (IP) in nasal areas would be transduced into 
neural signals and brain areas rather akin to regions receiving inputs 
from traditionally thought-about Olf and VNO sources. An IP component to 
sexual behavior would be part of a symphony of nasal perceptions that 
also includes Olf and VNO signals. The molecules that prompt nasal
immunological responses in the non-Olfactory and non-Vomeronasal 
epithelia may be other than traditional odorants or pheromones. 

An IP component to sexual behavior suggests that heterosexuality and 
non-heterosexuality may have causal components closely related to 
mechanisms related to immunological recognition of self and not-self, 
recognition of and responses to H-Y and similar antigens, etc.

Ramifications are quite nifty: for instance, heterosexuality may derive 
from hetero-consistent establishment of clonal immuno cell lines and 
also from the suppression of certain clonal immuno cell lines -- whereby
embryo and/or fetus is immunological reacting to itself and to its 
mother. Similarly, variations such as homosexuality, transvestisim, and 
transsexualism (HM, TV, and TS) might have subgroups causally derived from 
patterned responses induced by immunologically encoded variations in 
clonal selection and/or clonal deletion, etc., with regard to self, 
not-self, sensing of mother as XX and sensing of self as XX or as XY.

That sexuality may have autoimmune-like components is, in a least a 
preliminary way, (i) consistent with William Turner's findings of altered 
maternal aunt/uncle ratios and infertility and spontaneous abortion within 
pedigrees of many homosexuals (Arch Sex Behav, May 1995), (ii) with 
anecdotal data indicating a higher than average rate of immuno-related 
traits within pedigrees of HM of my acquaintance, and (iii) also 
consistent with male HM birth-order findings as reported by Ray Blanchard 
and colleagues (and see cites in their articles, eg newest Am J Psychiatry, 
Jan 1996). Also, inter-personal chemosensory and behavioral variations 
within families could derive from differing patterns of VDJ 
recombination, etc.

Teresa C. Binstock, Researcher
Developmental & Behavioral Neuroanatomy
Denver CO USA
			Teresa.Binstock at


Also, knowing that I've been assembling articles in research of and in 
support of the immuno/nasal/sexuality integration, one colleague recently 
forwarded me a summarized glimpse into the work of another person 
who has been focusing upon pheromonal/immunological/neuropeptide 
interactions in circumstances with sexuality-related interactivity.

If anyone knows of references (other than Blanchard and colleagues 
and their cites, which included Gualtieri and Hicks, 1985) wherein the 
authors document or hypothesize about chemosensory immunological 
perceptions as an active component in human sexual desire, I'd very much 
appreciate being informed thereof.



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