IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP

Neuronal products of anaerobic metabolism

Dr. Karim Brohi karim at trauma.org
Wed Jul 10 16:22:50 EST 1996

We are about to undertake a large research project studying our head 
injury patients with transcranial doppler ultrasound, CFM , Near 
Infrared spectroscopy and Jugular venous bulb monitoring.  Starting in 
the acute phase of injury (within 2-3 hours of the accident)  
Among other limbs of this project we will be measuring jugular venous 
lactate levels.  This has however shown to be a poor or late sign of 
cerebral hypoxia, levels not rising significantly until jugular venous 
haemoglobin saturations have fallen to 50%.  I presume most or all of 
this lactate is glial in origin.

Does anybody know of a substance (that can be measured) released by 
neurons in the early stages of hypoxia, preferably before neuronal 

Dr. Karim Brohi BSc FRCS
Trauma & Critical Care Unit, Royal London Hospital
Mailto:karim at trauma.org

More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net