Postdoctoral position available to examine the molecular mechanisms
underlying neuronal apoptosis/necrosis.
Our laboratory is focused on identifying genes induced in several model
systems, evaluating the "apoptotic" role of genes already identified, and
elucidating the mechanisms leading to the gene inductions, with particular
emphasis on oxidative stress and kinase pathways. Systems under analysis
include (i) a model of physiologically-appropriate programmed cell death
during development, i.e., NGF-deprived sympathetic neurons, (ii) a model
of physiologically-inappropriate neuronal death with potential disease
relevance, i.e., beta-amyloid treated primary cortical cultures, (iii)
models comparing oxidative-stressed induced apoptosis and necrosis, and,
(iv) Alzheimers disease and control autopsy brain tissue. This is an NIH
R01 funded position at a P50 Alzheimer Center, which has relevant
strengths in oxidative stress and neuronal death. Excellent opportunity to
work in a stimulating research area in a positive lab environment, and
live in an enjoyable college town. Fax or email brief statement of
research interests, curriculum vitae, and names and addresses of three
references to Steven Estus, Ph.D., Center on Aging, Univ. Kentucky,
Lexington, KY 40536, fax: (606) 323-2866, email:
sestus at aging.coa.uky.edu.
Relevant Publications include:
R. S. Freeman, S. Estus, K. Horigome, and E. M. Johnson, Jr.. Cell death
invertebrates and (maybe) vertebrates. Curr. Opin. Neurobiology.
R. S. Freeman, S. Estus, K. Horigome, and E. M. Johnson, Jr.. Analysis of cell
cycle-related genes in post-mitotic neurons: selective induction
of cyclin D1
during programmed cell death. Neuron 12 343-355 (1994).
S. Estus, W. J. Zaks, R. S. Freeman, M. Gruda, R. Bravo, and E. M.
Altered gene expression in neurons during programmed cell death;
of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127:
J. Ham, C. Babij, J. Whitfield, C.M. Pfarr, D. Lallemand, M. Yaniv, L.L.
c-Jun dominant negative mutant protects sympathetic neurons
cell death. Neuron 14: 927-939 (1995).
A. J. Anderson, C. J. Pike, C.W. Cotman. Differential induction of
gene proteins in cultured neurons by ß-amyloid (Aß): Association
of c-jun with
Aß-induced apoptosis J. Neurochem. 65: 1487-1498 (1995).
S. Estus, C. van Rooyen, M. Mattson, E.F. Brigham, and R.E. Rydel.
altered gene expression during neuronal death induced by NGF
amyloid ß-protein treatment, or glucose deprivation. Soc.
Neuroscience Abs. 21: