Cannabinoids Receptors Are Involved in Schizophrenia

Claude de Contrecoeur Cyrano at beehive.twics.com
Wed Jun 5 07:31:31 EST 1996


Pantagruelion
Cannabinoids receptors and schizophrenia:From Haschich to Schizophrenia
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Apparently,no research yet has been made concerning the involvement of cannabinoids 
receptors and schizophrenia.However,direct introspective observations with Cannabis 
sativa,together with theoretical considerations about thoughts abnormality in 
schizophrenics,lead to the strong feeling that anandamide(or other similar endogenous 
cannabinoid-mimetics)is,definitely,involved in the disturbed thought process of 
schizophrenics.Especially,anandamide function should be disturbed in the hippocampus 
and in other
 areas involved in memory or recall(the hippocampus is a structure of convergence 
where stored memories in different parts of the brain converge in order to be 
recalled.The hippocampus is essential for remembering,not for memorising per se).
Cannabinoids induce a phenomenon called "illusion" which is something completely 
distinct from hallucinations.Illusions are the main phenomena which give rise to the 
peculiar thinking of schizophrenics.

The Illusionised Consciousness or the Schizophrenic Mind
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In I845,Dr Joseph Moreau de Tours published his famous book about haschich and madness 
under the title:Du Haschich et de l'Aliénation Mentale(Masson,Paris I845,France).
This book was translated into English only in the I97O's through Raven Press,if my 
memory is correct.
Moreau de Tours was a real savant,a man curious about everything and willing to test 
"experimental madness", induced by haschich, in order to try to understand real 
madness.
His book has been unequaled ,as far as introspection is concerned.With this book 
Joseph Moreau de Tours became the father of introspective 
psychopharmacology.Unfortunately,he did not have many spiritual sons in this field 
until now,as some "scientists" think that rats and mice can better report what they 
feel under psychotropic drugs!
Moreau de Tours ,accurately ,perceived that haschich had something to do with real 
madness because haschich can induce illusions.So what are illusions?
Illusion is a state of consciousness where exogenous perceived informational patterns 
are wrongly identified by memory.This error of identification leads to false 
recognition of exogenous patterns which,in turn,leads to false consciousness of 
events.The phenomenon of illusion can make us conscious,"aware",of things which are 
non-existent in the exogenous reality(exoreality)! It is through this phenomenon that 
a schizophrenic can correctly perceive an outside person but wrongly identify this 
person as som
eone else like,let say,Napoléon or the Virgin Mary,etc.Illusions should not be 
confused with hallucinations as these phenomena are completely 
different.Hallucinations alone are not sufficient to transform a normal person into a 
schizophrenic while illusions are sufficient per se.To be crazy you just need to be 
illusionised! As the stimulation of cannabinoid receptors lead to illusions,it is then 
very logical to deduce that anandamide(and related endogenous compounds)should play a 
crucial role in schizoph
renia.This remains to be investigated but I have no doubt that indeed disturbances of 
anandamide functions will be found in schizophrenics.As illusions are also very common 
in normal dreams,anandamide metabolism in the dream state should be different from 
anandamide metabolism in the waking state.New medications blocking the action of 
anandamide on cannabinoid receptors could well be novel antipsychotics!

Claude Rifat



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