Are _forskolin_ and _U69593_ cAMP inhibitors?
chbarry at llnl.gov
Thu Jun 13 18:42:49 EST 1996
> I think that kappa opioid receptors are belived to couple via pertussis
> toxin-sensitive Gi/Go proteins to the inhibition of calcium channels.
> Now, Gi can also inhibit adenylyl cyclase, and there is evidence that Go
> can do the same. So that could explain an inhibitory effect on [cAMP] by
Aren't 4 Ca++ 's required for maximal AC activity? If so, A receptor
that activates the adenylate cyclase via the inositol pathway could be
inhibited by a Ca++ channel blocker. ie:
Ligand --> receptor
\/ | ???
Gp-prot-----> phospolipase c---->C-kinase------>Adeny-
| ^ late
\/ | Cyclase
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