Are InsP3 and Intracellular Ca+2 Related to Microfilament Elongation ?

Zanos Stavros stavrosz at
Fri Mar 29 23:27:04 EST 1996

In a recent issue of TINS, Edwards (1995) suggests that a key-stage in the 
changes evoked by LTP induction is the "...elongation of the microfillaments 
that are attached to the postsynaptic density, tending to cause it to bend up 
and perforate". He also suggests that a most possible mechanism for 
triggering of this process is the activation of metabotropic Glu receptors 
(mGluRs), through the formation of InsP3 and the release of intracellular 
Ca2+ from the spinal smooth ER. The author however does not mention any 
findings relating either of these two factors to a possible change in 
microfilament status.

Is anybody aware of any such findings ? 

That would be a great deal of help to me, since I need this kind of info in 
order to finish my part of a seminar-presentation, concerned with the 
molecular/cellular correlates of learning. On the other hand, this conceptual 
model seems rather attractive, and (as noted by the author) it could 
potentially unify (?) the widely different approaches used so far to explain 
the expression of LTP.

Thank you mostly, in advance.

Edwards F.A. (1995) LTP -  A Structural Model to Explain the Inconsistencies. 
Trends Neurosci. 18: 250-255

Zanos Stavros
Aristotle Univ School of Medicine
Thessaloniki, Macedonia, Greece

		"If I had more time, I would have written you a shorter letter"

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