Glycine in CNS

djw3610 at djw3610 at
Wed Nov 13 16:13:16 EST 1996

In the earlier part of this decade clinical trials were performed using
L-threonine for the treatment of amyotrophic lateral sclerosis (als). My
understanding is that L-threonine is a precurser to glycine and that the
purpose of the experiment was to generate increased glycine production in
the CNS and thereby inhibit the effects of excess glutamate. 

My Question is this:. Would not glycine, ingested orally,  be more
effective in raising CNS levels of glycine?

Regards, Dan

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