Mariano Viapiano mviapiano at
Mon Oct 14 01:14:44 EST 1996

I work on GABAa receptors and propofol behaves as a modulator of these
receptors. I hope these references may help:

1)MV Jones, NL Harrison, DB Pritchett, TG Hales
Modulation of the GABA(A) receptor by propofol is independent of the gamma
Journal of Pharmacology and Experimental Therapeutics 274: 2 (AUG 1995) 962-968

2)E Sanna, MP Mascia, RL Klein, PJ Whiting, G Biggio, RA Harris
Actions of the general anesthetic propofol on recombinant human GABA(A)
receptors: Influence of receptor subunits
Journal of Pharmacology and Experimental Therapeutics 274: 1 (JUL 1995) 353-360

3)Effects of propofol, pentobarbital and alphaxalone on T-[35S]butylbicyclo-
phosphorothionate binding in rat cerebral cortex.
Concas-A; Santoro-G; Mascia-MP; Maciocco-E; Dazzi-L; Biggio-G
Eur-J-Pharmacol. 1994 Apr 15; 267(2): 207-213

4)E Sanna, F Garau, RA Harris
Novel properties of homomeric beta 1 gamma- aminobutyric acid type A receptors:
Actions of the anesthetics propofol and pentobarbital
Molecular Pharmacology 47: 2 (FEB 1995) 213-217

4)Propofol potentiates the binding of [3H]FNZ to the GABAa receptor complex
Prince RJ; Simmonds MA
Brain Res (NETH), Nov 20 1992, 596 (1-2) p238-42

5) Propofol and barbiturate depression of spinal nociceptive neurotransmission
Jewett BA; Gibbs LM; Tarasiuk A; Kendig JJ.
Anesthesiology (USA) Dec 1992, 77 (6) p1148-54  // Comment in Anesthesiology
Dec 1992, 77 (6) p1059-61

My best wishes.

Mariano Viapiano

Instituto de Biologia Celular y Neurociencias
Facultad de Medicina, Universidad de Buenos Aires
Paraguay 2155, 3p (1121), Buenos Aires, Argentina
FAX: (54 1) 788-5885
e-mail:viapiano at

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