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Fever and ADHD (attention deficit hyperactivity disorder)

F. Frank LeFever flefever at ix.netcom.com
Mon Feb 3 00:10:33 EST 1997

re Neal Prakash's commentary: my reply to the original query (reply is
header #16908, at least via my server) discussed the IL-1 angle. In
addition to Linda Watkins re vagus, check out Robert Dantzer re
exploratory behavior, operant behavior, etc.

In my earlier comment, I speculated re IL-1 effect on Ne
(noradrenaline), the target most prominent in theories of ritalin
(etc.) action in ADD (although dopamine should not be ignored).  I did,
indeed find a very good review of IL-1 effects on classsical
neurotransmitters, including increasing Ne activity--but left it at
work!  will try to bring it home tomorrow.  Believe it was in
Neuroimmunology, 1996 or possibly 1995.

Frank LeFever
New York Neuropsychology Group

In <Pine.GSO.3.95.970202145837.25667A-100000 at taurus.oac.uci.edu> Neal
Prakash <nprakash at taurus.oac.uci.edu> writes: 
>Sorry, I missed the original post.
>But I recall that there is a growing body of research linking "illness
>behaviors" (i.e. fever, decreased socialization, etc.) with immune
>cytokines acting directly on the brain.  I don't recall the exact
>right now, try L. Watkins [?] or keywords: IL1, fever, vagus, if you
>access to medline. 
>One belief is that peripheral nerves, but especially the vagus nerve,
>receptors for cytokines, such as IL1, TNF-b, and IL6. So when you have
>infection, local cytokines activate the vagus nerve, which in turn
>mediates illness responses in the central nervous system via the
>Perhaps, with ADHD, this response is altered. Or maybe the illness
>response in the hypothalamus counteracts the neurochemical pathways
>involved in ADHD...
>On 2 Feb 1997, Wernerson wrote:
>> Why is my child less hyperactive and why does he get better
attention when
>> he have a fever ?
>> I wonder if science has ever picked up on this point and tried to
>> trace from there ?
>> There must be a connection between body temperature and brain
activity ?
>-Neal Prakash 
>Department of Psychobiology, College of Medicine

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