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Arachidonyl ethanolamide biosynthesis

Howard Olson howard.olson at awaiter.com
Sun Feb 2 22:37:15 EST 1997


   
     Arachidonyl ethanolamide, also known as anandamide (the natural
cannibinoid ligand in the Human CNS) is apparently synthesised by the
enzyme ethanolamine phosphotransferase. Dr. Jack G. Chamberlain (1996)
has suggested that this enzyme was responsible for sequestering Highly
Unsaturated Fatty Acids (HUFA) such as arachidonic and eicosapentaenoic
acid from dietary sources during the evolution of the hominid brain.

     This is significant because Chamberlain, an anatomist, and some
anthropologists argue that HUFAs were essential for the unique
development of the primate brain in general and the human brain in
particular.
                                                           
     Since anandamide is the ethanolamide of the HUFA arachidonic acid
it seems possible that this cannibinoid ligand and its central receptor
have played a role in brain evolution. Thus, THC in the form of Medical
Marijuana may have an important role in neurochemical evolution and high
relevance to human psychopharmacology. This is another issue that the
NIH should investigate carefully despite pressure from Federal Narcs to
support the statist quo (sp. intentional).


Chamberlain, JG (1996) THE POSSIBLE ROLE OF LONG CHAIN, OMEGA-3 FATTY
ACIDS IN HUMAN BRAIN PHYLOGENY

PERSPECTIVES IN BIOLOGY AND MEDICINE Vol 39, No. 3, Spring 1996


                Howard R. Olson, MA
                Bioethicist





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