In <01bc185c$cbea0260$2158cf9b at slirp.hol.gr> "Stavros P. Zanos"
<stavrosz at med.auth.gr> writes:
>>>F. Frank LeFever <flefever at ix.netcom.com> wrote in article
><5dbkeg$i1g at dfw-ixnews11.ix.netcom.com>...
>>> A few years ago, Don Stein reported that intracerebral
>> of NGF improved pperformance of rats with cerebral lesions, but not
>> normal rats; indeed, may have impaired performance of normal rats.
>>This has been shown in several studies since then.
CAN YOU GIVE REFERENCES? OR AT LEAST NAME OF AUTHOR(S) AND APPROXIMATE
It seems that while NGF
>improves performance in impaired animals (e.g. aged rats, rates with
>cerebral lesions etc.), it has the opposite effects when administered
>young or intact animals.
>>NGF is vital for the development and survival of basal forebrain
>cholinergic neurons. When administered intraventricularly or
>intracerebrally (or even systematically, as reported by Backman et al.
>(1996) J. Neurosci. 16, 5437) it prevents cholinergic neuron loss; it
>induces increases in the complexity and vastness of the dendritic
>these neurons. NGF administration to young adult animals may trigger
>sprouting of intact cholinergic fibers, which leads to undesirable
>modification of basal forebrain cholinergic system function and
>behavioral impairments. For example see:
>>Crutcher KA, Saffran BN (1990) Soc Neurosci Abstr 16:993
>Saffran, Crutcher (1990) Brain Res 525:11.
>>Hope this helps.
>Aristotle University Faculty of Medicine
THANKS FOR THE REFERENCES; SOME ASPECTS OF THE LONG-TERM EFFECTS MAY BE
RELEVANT. (if nothing else, will contribute to my overall
understanding of NGF; one interest is in two-way NGF/mast cell
relationship...) HOWEVER, STILL HOPING YOU OR SOMEONE CAN STEER ME TO
STUDIES OF ACUTE EFFECTS!
New York Neuropsychology Group