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kinetics of COMT

Dr David Nicholl d.j.nicholl at bham.ac.uk
Wed Feb 19 12:49:52 EST 1997

MR CS BOYD wrote:
> I would appreciate it if someone could help me the following info regarding
> neuronal COMT :
> Km value for S-adenosylmethionine (its cofactor)
> Km values for the substrates : dopamine, noradrenaline, L-dopa
> It was also be extremely helpful if you can please cite a reference source
> for the values obtained.
> Thank you
> Clinton Boyd
Have you looked at Lotta et al. Kinetics of human soluble and
membrane-bound catechol 0-methyltransferase. Biochemistry
1995,34:4202-4210? Although I'm not aware of any work which has
specifically looked at 'neuronal COMT'. Since membrane bound COMT is the
predominant form in the CNS, this paper may help you.

Yours Sincerely,      

Dr David Nicholl
Dept of Neurology
Queen Elizabeth Hospital
B15 2TH

Tel/Fax +44 121 627 2061
Departmental WWW home pages at http://medweb.bham.ac.uk/clin_neuro.html

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