A colleague and I are writing a somewhat speculative article on the
subject of prion diseases, and I was wondering if anyone could
direct me to any papers or articles which answer any of the following
Assuming that the protein-only hypothesis of prion transmission is
1. Is it known whether or not the protein affected in the human
diseases Kuru, Creutzfeldt-Jakob disease (CJD) and
Gerstmann-Straussler syndrome (GSS), is the same protein in
2. Are there any papers which outline the time-scales or
pathology of these diseases?
3. Is it known whether or not the prion-like protein recently
discovered in yeast is any relation of the afflicted proteins
in humans? (I've been unable to get hold of the reference
I have for this)
Any assistance would be gratefully received.