In article <5ehd9m$315 at crocus.csv.warwick.ac.uk>, lsrgi at csv.warwick.ac.uk (Mr A Yool) writes:
> Hello everyone,
>> A colleague and I are writing a somewhat speculative article on the
> subject of prion diseases, and I was wondering if anyone could
> direct me to any papers or articles which answer any of the following
> questions :
>> Assuming that the protein-only hypothesis of prion transmission is
>> 1. Is it known whether or not the protein affected in the human
> diseases Kuru, Creutzfeldt-Jakob disease (CJD) and
> Gerstmann-Straussler syndrome (GSS), is the same protein in
> each disease?
Yes, the PrP protein.
>> 2. Are there any papers which outline the time-scales or
> pathology of these diseases?
Nice chaty article by Prusiner (who invented the Prion hypothesis) in Scientific
American (January 195) gives a very brief summary (one table).
> 3. Is it known whether or not the prion-like protein recently
> discovered in yeast is any relation of the afflicted proteins
> in humans? (I've been unable to get hold of the reference
> I have for this)
If it is a Prion LIKE protein, then that usually means that it is indeed
a relation of the human PrP protein as the likeness is usually just from
sequence comparison (rather than similar expression patterns in the brains of
the two species).
UCC, Cork, Ireland.
> Any assistance would be gratefully received.