Inflammatory mechanisms in Parkinson's disease

Serge Helfrich s.helfrich at mailhost.net
Mon Jan 13 10:10:16 EST 1997


Hi!

I'm working on some preparations for a research on the pathogenesis of
(idiopathic) Parkinson's disease in relation to the increment of
inflammatory proteins in certain brain regions. I'm wondering if the
involvement of interleukins merely concerns the process of
neurodegeneration or that it in fact reflects a mechanism of
compensation, i.e. that those proteins act as neurotrofic factors.

A possible mechanism of interleukin induction involves the activation of
transcription factor NF-kappa B by reactive oxygen intermediates
(Kaltschmidt et. al. 1993, Mol. Asp. Med. 14:171-190). So there seems to
be a link with the oxidative stress hypothesis.

Any useful ideas on this?

Greetz,

Serge Helfrich

s.helfrich at organon.akzonobel.nl
helfrich at xs4all.nl




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