help me!

F. Frank LeFever flefever at ix.netcom.com
Wed Jan 15 19:50:07 EST 1997


In <01bc02dd$21feb5a0$897aa7c2 at DORADE.esa5017.u-bordeaux2.fr> "Pierre
AUBINEAU" <pierre.aubineau at hippocrate.u-bordeaux2.fr> writes: 
>
>
>
>Gianluk from G.m.S. <gianluk at thepentagon.com> a écrit dans l'article
><32dc1ac7.1935788 at news.interbusiness.it>...
>> I am an italian boy of 22 years.
>> From 2 years I suffer of headache. Also taking medicinal I am not
able
>> to resolve 
>> my problems.
>>
I'll post here so people who have read the message below mine will see
it without having to scroll through it--but please read it if you have
not; I concur.

I just want to encourage a look at piroxicam (Feldene).  Long known as
an NSAID, used mainly in arthritis, etc., it has some unusual other
possible uses.  One relevant here is in relieving pain and photophobia
of migraine.  One study (SPECT?) suggested that in contrast to
indomethacin's uniform vasoconstriction, piroxicam corrected the
vasomotor dysregulation, selectively.

Favorable response to indomethacin has been considered diagnostic of
hemicrania continua; one can now add piroxicam to this
diagnostic/treatment approach.

It is known to block some behavioral/cognitive effects of IL-1, and one
(arthritis) study suggested one mode of action may be enhanced
production of endogenous IL-1 antagonist (receptor competitor ), IL-1a.

I WOULD BE INTERESTED IN DATA OR ANECDOTAL ACCOUNTS OF "unusual"
(NON-PDR) SIDE EFFECTS OR USES OF PIROXICAM.

n.b.: tenoxicam (hydrophilic) may or may not have similar effects
(piroxicam is more lipophilic).

Frank LeFever
New York Neuropsychology Group












 
>>Depending on your case, a multiplicity of treatments now exist
against
>cluster headache (if it is true C.H.). I'm working with a specialized
>department in Bordeaux (France) and I do fundamental research on this
>pathology. The adequation of potential treatments (either preventive
or
>symptomatic or both) necessitates a precise diagnostic which cannot be
>established at distance. Usually, attacks can be prevented by taking
>regularly various classes of treatments (which have to be adapted to
your
>particular case). If not, you can try "attack treatments" which, in
the
>majority of cases, are efficient in aborting the attack. The most well
>known, presently, is Sumatriptan from Glaxo laboratories (speciality
name:
>Imigrane, in France).
>But I insist on the fact that you have to be examined in a specialized
>neurology departement in order to determine what is convenient for
your
>disease.
> 




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