Arachidonyl ethanolamide biosynthesis

Howard Olson holson at california.com
Fri Jan 31 04:44:37 EST 1997


howard.olson at awaiter.com (Howard Olson) wrote:

>   
>     Arachidonyl ethanolamide, also known as anandamide (the natural
>cannibinoid ligand in the Human CNS) is apparently synthesised by the
>enzyme ethanolamine phosphotransferase. Dr. Jack G. Chamberlain (1996)
>has suggested that this enzyme was responsible for sequestering Highly
>Unsaturated Fatty Acids (HUFA) such as arachidonic and eicosapentaenoic
>acid from dietary sources during the evolution of the hominid brain.

>     This is significant because Chamberlain, an anatomist, and some
>anthropologists argue that HUFAs were essential for the unique
>development of the primate brain in general and the human brain in
>particular.
>                                                           
>     Since anandamide is the ethanolamide of the HUFA arachidonic acid
>it seems possible that this cannibinoid ligand and its central receptor
>have played a role in brain evolution. Thus, THC in the form of Medical
>Marijuana may have an important role in neurochemical evolution and high
>relevance to human psychopharmacology. This is another issue that the
>NIH should investigate carefully despite pressure from Federal Narcs to
>support the statist quo (sp. intentional).


>Chamberlain, JG (1996) THE POSSIBLE ROLE OF LONG CHAIN, OMEGA-3 FATTY
>ACIDS IN HUMAN BRAIN PHYLOGENY

>PERSPECTIVES IN BIOLOGY AND MEDICINE Vol 39, No. 3, Spring 1996


>                Howard R. Olson, MA
>                Bioethicist







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