Calea zacatechichi

Claude de Contrecoeur cyrano at pasdemerde.touic.comu
Mon Jun 16 07:13:52 EST 1997


[Entrez-med-query]

Other Formats:  [MEDLINE Format]
Links:  [106 medline neighbors]

J Ethnopharmacol 18 (3): 229-243 (1986)

Psychopharmacologic analysis of an alleged oneirogenic plant: Calea
zacatechichi.

Mayagoitia L, Diaz JL, Contreras CM

Calea zacatechichi is a plant used by the Chontal Indians of Mexico to
obtain divinatory messages during dreaming. At human doses, organic
extracts of the plant produce the EEG and behavioral signs of
somnolence
and induce light sleep in cats. Large doses elicit salivation, ataxia,
retching and occasional vomiting. The effects of the plant upon
cingulum
discharge frequency were significantly different from
hallucinogenic-dissociative drugs (ketamine, quipazine, phencyclidine
and
SKF-10047). In human healthy volunteers, low doses of the extracts
administered in a double-blind design against placebo increased
reaction
time and time-lapse estimation. A controlled nap sleep study in the
same
volunteers showed that Calea extracts increased the superficial stages
of
sleep and the number of spontaneous awakenings. The subjective reports
of
dreams were significantly higher than both placebo and diazepam,
indicating
an increase in hypnagogic imagery occurring during superficial sleep
stages.

MeSH Terms:

   * Adult
   * Analysis of Variance
   * Animal
   * Behavior, Animal/drug effects
   * Cats
   * Diazepam/pharmacology
   * Double-Blind Method
   * Dreams/drug effects*
   * Electroencephalography
   * Female
   * Human
   * Male
   * Mexico
   * Plant Extracts/pharmacology
   * Plants, Medicinal*
   * Psychotropic Drugs*
   * Random Allocation
   * Reaction Time/drug effects
   * Respiration/drug effects
   * Sleep/drug effects*
   * Time Perception/drug effects*

Substances:

   * Diazepam
   * Plant Extracts

PMID: 3821139, MUID: 87142942

---------------------------------------------------------------------------

 the above report in  format.

---------------------------------------------------------------------------




More information about the Neur-sci mailing list