Distribution of Succinic Semialdehyde Reductase in rat brain(GHB)

Claude de Contrecoeur cyrano at pasdemerde.touic.comu
Sun Jun 22 21:42:49 EST 1997



M.C. 7 (1): 13-20 (Février 1997)

Distribution of succinic semialdehyde reductase in rat brain
-------------------------------------------------------------------------------------------
Par:

Li JE, Choi SY, Suk JW, Hong JW, Yoo BK, Choi EY, Jang SH, Park KA,
Cho SW

Département d'Anatomie, Université de Yonséï,Ecole de
Médecine,Séoul,Corée

Succinic semialdehyde reductase (SSR) that catalyzes the reduction of
succinic semialdehyde (SSA) to gamma-hydroxybutyrate (GHB) has been
identified as one of the NADPH-dependent aldehyde reductases.
Reduction of
SSA to GHB strongly supports the proposal that GHB biosynthesis may be
an
important step in the GABA shunt. It is pharmacologically significant
in
anesthesia, evoking the state of sleep, and an increase in brain
dopamine
level. Monoclonal antibodies against bovine brain succinic
semialdehyde
reductase were produced. Using the anti-succinic semialdehyde
reductase
antibodies, we investigated the distribution of brain succinic
semialdehyde
reductase in rat brain. The brain tissues were sectioned with a basis
on
the rat brain atlas of Paxinos and were stained by the
immunoperoxidase
staining method using monoclonal antibodies. 

In the section of the frontal lobe, immunoreactive cells were observed
in the lateral septal area, the ventral pallidum, which belongs to the
substantia innominata. We could observe immunoreactive cells in the
reticular thalamic nucleus, which is closely related with "sleeping',
the basal nuclei of Meynert, which is associated with Alzheimer's
disease, and hypothalamic nuclei.

Ces deux observations sont très intéressantes et méritent des études
précises chez les Mammifères supérieurs.

Immunoreactive cells were also shown in raphe nuclei or the reticular
formation

Egalement à suivre!

of the midbrain, cerebellum, and inferior olivary nuclei of the
medulla oblongata. Succinic semialdehyde reductase-immunoreactive
cells
were distributed extensively in rat brain, especially immunoreactive
cells
were strongly observed in the areas associated with the limbic system
and
reticular formation.

Ce travail implique des travaux beaucoup plus considérables car il
ouvre des portes nouvelles quant au pourquoi des récepteurs au
gamma-hydroxybutyrate.Remarquons les distributions ici indiquées.



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