Transgenic mice.

Joseph Cheer _ Coordinador de Neurobiologia. FINC _ cheer at
Wed Mar 12 09:29:42 EST 1997

Dear sirs,

I am a Biologist who will start a PhD in Molecular Neuropharmacology 
this fall. I am very interested in the use of transgenic mice (specially the 
use of embryonic stem cells as a vehicle to mutate specific genes). I do 
have some protocols but I have one question that seems to remain 
unanswered. After pro nuclear microinjection how does the DNA template 
integrate the host genome. Is it by homologous recombination? I would 
like to know what the exact mechanism is. Could please shed some light in 
this subject for me?

Thank you in advance for your replies

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