Chronic studies, Serial lesions, ischemic preconditioning, etc.

F. Frank LeFever flefever at
Sat Mar 15 00:33:54 EST 1997

In <5g5ese$j19 at> flefever at Frank
LeFever) writes:

One or two helpful repiles.  Looking for more!


>Still interested.  (no response yet)   Also, ANY truly chronic studies
>even if only one trauma  (posted longer query re chronic studies--but
>don't see it!)
>In <5g2i08$b35 at> flefever at Frank
>LeFever) writes: 
>>The serial lesion paradigm (e.g. as described in the Finger & Stein
>>book on recovery from brain trauma a few years ago) typically
>>a first and second lesion separated by rather short intervals--e.g.
>>hours, days, at most 2-3 weeks.  Ditto ischemic preconditioning:
>>resistance to a second ischemic event relatively soon after the first
>>Does anyone know of studies (published, unpublished, old or still in
>>progress) of "conditioning" or "priming" lesions followed MUCH, MUCH
>>later than a second lesion?
>>I know, of course of "experiments of nature", in which humans
>>a second concussion years after the first typically have more (rather
>>than less) severe symptoms than one might otherwise expect.  I am
>>looking for animal studies.
>>I'm not fussy: I'll gladly accept studies with analyses at ANY level:
>>behavioral, neurochemical, histological, etc.
>>For replies too long for e-mail: FAX (914) 947-3350
>>                                        or
>>                         LeFever, Helen Hayes Hospital
>>                         West Haverstraw, NY 10993, USA
>>F. Frank LeFever, Ph.D.
>>New York Neuropsychology Group

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