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brain cell regeneration

Brian Scott brians at interlog.com
Wed May 14 17:51:25 EST 1997


In article <3379ace4.1156390 at news.frii.com>,
Paul Ostrof <paulo at frii.com> wrote:
>What research is being done in regenerating dead brain cells?  Is any
>progress being made?
>

Bringing dead brain cells back to life?!!!  Wow!  Neuroscientists can do 
some pretty nifty things eh?  :-)

If you're interested in replacing dead brain cells with new and fully 
functional neurons then have a look at these papers for a start:

Gage, FH, Coates, PW et al.  (1995).  Survival and differentiation of 
adult neuronal progenitor cells transplanted to the adult brain.  Proc. 
Natl. Acad. Sci. USA, 92:11879-11883.

Gage, FH, Ray, J and Fisher, LJ  (1995).  Isolation, characterization, 
and use of stem cells from the CNS.  Annu. Rev. Neurosci., 18:159-92.


These two articles deal with the use of multi-potent stem cells and/or 
neural progenitors.  Look for transplantation in Parkinsons Disease too, 
where non-neuronal cells are being engineered to produce dopamine or a 
precursor.  There's lots of neat stuff going on.

Brian



-- 
Brian Scott           | "A man is rich in proportion to the number of things 
brians at interlog.com   |  which he can afford to let alone."
Dept. of Physiology   |
University of Toronto |  - Henry David Thoreau (1817-1862)



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