Zyban (bupropion, welbutrin), DHEA, Smoking, and Depression
jmhoward at sprynet.com
Tue Oct 7 13:13:49 EST 1997
If you will read my theory of sleep at http://www.naples.net/~nfn03605
on the web, you will read that I think REM sleep is the result of
increased DHEA at night, during sleep. I posted here, in the past, my
suggestion that instead of zyban, one might take DHEA to help with
stopping smoking. Also, here at the section on "depression," I have
posted about DHEA and depression. That is, my work suggests depression
results from too little DHEA, or a break-down in the melatonin - DHEA
cycle, such that too little DHEA is available. In the following
quotation concerning zyban (bupropion), you may read that bupropion, an
antidepressant, shortens the time to REM sleep and increases REM sleep.
I suggest this is the effect of zyban increasing DHEA.
Am J Psychiatry 1995 Feb;152(2):274-276
"REM sleep enhancement by bupropion in depressed men," Nofzinger EA,
Reynolds CF 3rd, Thase ME, Frank E, Jennings JR, Fasiczka AL, Sullivan
LR, Kupfer DJ Sleep and Chronobiology Center, University of Pittsburgh
School of Medicine, Western Psychiatric Institute and Clinic, PA 15213.
"OBJECTIVE: The authors compared the effects of bupropion, fluoxetine,
and cognitive behavior therapy on EEG sleep in depressed subjects.
METHOD: All-night sleep EEG studies were performed before treatment and
after partial or full remission on 18 men with depression diagnosed
according to Research Diagnostic Criteria and randomly assigned to
treatment with either bupropion (N = 7) or fluoxetine (N = 11). Response
to these drugs was measured by changes in Hamilton Depression Rating
Scale scores. Pre- and posttreatment EEG sleep study results before and
after treatment with cognitive behavior therapy were also available for
18 men matched in age and severity of Hamilton depression scale score,
and one-time EEG sleep measures were available for 36 men who were not
depressed. RESULTS: REM latency was reduced and REM sleep percent and
REM time increased after treatment in the depressed men given bupropion.
These effects contrasted with the effects of fluoxetine and cognitive
behavior therapy. CONCLUSIONS: This study represents the first report of
an antidepressant medication that shortens REM latency and increases REM
sleep. If confirmed, this finding may require a revision of our current
understanding of the relation among depression, REM sleep, and
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