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NEUROPSYCHOLOGY Conference Oct. 17,18 1997. Montreal

Gabriel Leonard leonard at PO-Box.McGill.CA
Fri Sep 12 11:15:21 EST 1997


       Neuropsychology Beyond the Millennium
               La Neuropsychologie Après l'an 2000
                     October 17 & 18 Octobre
                    Jeanne Timmins Auditorium
                 Montreal Neurological Institute
                      3801 University Street
                       Montréal, Qc. H3A 2B4
                  Keynote speaker: Brenda Milner

              Neuropsychology: Past, Present and Future
                      Gabriel Leonard, Ph.D
                        Alain Ptito, Ph.D

           Montreal Neurological Institute and Hospital
                       McGill University 
INFORMATION: e-mail:   leonard at ego.psych.mcgill.ca
              Phone:   514-398-8905 
                Fax:   514-483-2880 or 514-398-1338

Please visit our WEB site for full information and registration form.


Cost:  $190.00 for students   $150.00 each for five or more students
       $300 for professionals $250.00 each for five or more professionals

Payable to: Neuropsi 3000
            215 Wolseley North
            Montreal West
            Quebec, Canada, H4X 1W1 

                      VENDREDI 17 Octobre
                      FRIDAY October 17th

 Day 1           Faculty
                 Alain Ptito
                                  Introduction and welcoming remarks
                 Brenda Milner
                                  Neuropsychology: Past, present, and future
                 Maurice Ptito
                                  Human Neuroanatomy
                 Tomas Paus
                                  Functional & Structural Neuroimaging:
                                  Principles of PET, fMRI & MRI
                 Robert Zatorre
                                  Neuroimaging: Application to Perception
                                             & Cognition
                 Jean-Guy Villemure
                                  Neurosurgery and Neuropsychology:
                                             Inseparable Specialties

Day 2                       SAMEDI 18 Octobre
                          SATURDAY October 18th

                 Michael Petrides
                                    Functional Organization of the Frontal
                 Marilyn Jones-Gotman
                                    Measuring Memory in Health & Disease
                 Julien Doyon
                                    Neuropsychology of Normal &
                                    Pathological Aging.
                 Adele Diamond
                                    Development of Frontal Lobe Functions
                                    in Children
                 Harvey S. Levin
                                    Closed head injury: Mechanism,
                                    diagnosis, and rehabilitation.
                 Gabriel Leonard

The following is a profile of some of the speakers:                      
Dr. Brenda Milner Brenda Milner was born in Manchester, England and was 
educated at Newnham College Cambridge, receiving her B.A. in Experimental 
Psychology from Cambridge University in 1939, followed by an Sc.D. in 1972. At 
the end of World War II (which she spent doing applied research for
the U.K. Ministry of Supply), Milner moved to Canada, where she took up a 
teaching position at the newly formed Institut de Psychologie of the 
Université de Montréal. A turning-point came with the arrival of D.O. Hebb at 
McGill University in 1947. His book The Organization of Behavior was still in
manuscript, and each chapter was being vigorously debated in the weekly 
seminar, which Milner attended. In 1950, Hebb invited Milner to go to the 
Montreal Neurological Institute to study patients in
whom Dr. Wilder Penfield was carrying out unilateral brain operations for the 
relief of focal epilepsy.  She has remained there ever since, obtaining her 
Ph.D. in physiological psychology from McGill in 1952
and going on to establish a laboratory of neuropsychology at the Institute 
where she is currently the Dorothy J. Killam Professor of Cognitive 
Neuroscience. In 1964 Milner was appointed a Career
Investigator by the Medical Research Council of Canada.

Milner's early studies of human temporal-lobe function were influenced by the 
results of cortical ablation studies in the monkey that pointed to a major 
role for the inferotemporal cortex in visual discrimination
learning. The visual deficits that she observed in patients after right 
temporal lobectomy (but not after left) indicated a convergence between the 
findings for monkey and man, while underscoring the functional asymmetry of 
the human cerebral hemispheres. A new departure came with her delineation of
the devastating amnesic syndrome that follows combined bilateral destruction 
of the amygdala, hippocampus and parahippocampal gyrus, on the medial aspect 
of the temporal lobes: this included the demonstration of preserved learning 
of motor skills in patients with these lesions. These observations led
Milner to focus much of her subsequent research on the analysis of memory 
disorder. Thus, she and her students have demonstrated the important role 
played by the right hippocampal region in spatial memory
and by the frontal cortex in the temporal ordering of recent events. Milner 
has also explored the relationship between hand preference and speech 
lateralization and the effects of early unilateral brain
lesions on the pattern of cerebral organization at maturity.

Brenda Milner has received numerous honors, including the Isaak Walton Killam 
Award from the Canada Council, the Hermann von Helmholtz Prize from the 
Cognitive Neuroscience Institute, the Karl Spencer Lashley Award from the 
American Philosophical Society, the Ralph Gerard Prize from the
Society for Neuroscience, the Neural Plasticity Prize from the Ipsen 
Foundation (Paris), the Gordon G. Lennox Award from the American Epilepsy 
Society, and the Mclaughlin Medal from the Royal Society
of Canada. She is an Officer of the Order of Canada and of the Order of 
Quebec, a Fellow of both the Royal Society of London and the Royal Society of 
Canada and a Foreign Affiliate of the National Academy of Sciences of the 
United States. In recognition of her research achievements Milner will this
year be inducted into the Canadian Medical Hall of Fame. 

Dr. ADELE DIAMOND received her B.A. from Swarthmore College in 1975 with 
majors in bothpsychology and sociology-anthropology. She graduated with 
distinction, Phi Beta Kappa, and with NSF and Danforth Graduate Fellowships. 
Dr. Diamond was intrigued by the idea that a maturational change
in the brain may help make possible specific cognitive changes during the 
first year of life. Her dissertation examining this question was funded by an 
NSF doctoral dissertation grant, and she has received continuous federal 
funding ever since, from NIH.  Dr. Diamond's research focus is on the 
functions of dorsolateral prefrontal cortex and the interrelated
cognitive and perceptual-motor abilities that appear to require that neural 
system. She hypothesized that some of the cognitive advances seen in infants 
between 7.5-12 months of age are made possible by maturational changes in 
prefrontal cortex. By working with both macaques and children, and by studying
both behavior and brain function, she was able to establish one of the first 
and strongest direct links between cognitive development and the functions of 
a specific neural system. To look at the role of dopamine in early prefrontal 
cortex function, Dr. Diamond has been studying children in whom there was 
reason to believe that there might be a selective decrease in dopamine in
prefrontal cortex, without other abnormalities in the brain i.e., children 
treated early and continuously for phenylketonuria (PKU). Dr. Diamond and her 
colleagues have shown that these children are impaired in
the cognitive functions dependent on prefrontal cortex, while unimpaired on 
tests of the functions of parietal cortex or the medial temporal lobe. In an 
animal model, they investigated the underlying biological mechanism, and 
found, as predicted, that the problem appears to lie in the exquisite 
sensitivity of the prefrontally-projecting dopamine neurons to the modest 
reduction in CNS tyrosine levels found in these children. The dopamine neurons 
in the retina share this special sensitivity, and those neurons too
appear to be affected in these children: Reduced dopamine in the retina is 
associated with impaired contrast sensitivity, and children treated early and 
continuously for PKU have reduced sensitivity to visual contrast. This was the 
first demonstration of a visual defect in these children.  Before this work, 
neuropsychologists had begun to suspect that some children treated early and
continuously for PKU had deficits specific to the cognitive functions 
dependent on prefrontal cortex, but no one knew of a mechanism that would 
produce that kind of selective effect. Before this work, neuropharmacologists 
had been documenting the special characteristics of the dopamine projection to
prefrontal cortex in rats, but there was no evidence on whether this was also 
true in humans. Dr.  Diamond's work makes that connection and leads to obvious 
treatment implications, which she is
currently investigating.

Dr. Diamond is a teacher as well as a researcher, and she has been named a 
Lilly Foundation Faculty Teaching Fellow. She is both a developmental 
psychologist (a Fellow of Division 7 [Developmental
Psychology] of APA; member of SRCD and the International Society for Infant 
Studies; Ph.D. in developmental psychology, Harvard, 1983, with Jerome Kagan) 
and a neuroscientist (a Fellow of Division 6 [Behavioral Neuroscience & 
Comparative Psychology] of APA; member of Society for
Neuroscience, IBRO, and the Cognitive Neuroscience Society.

HARVEY S. LEVIN, Ph.D., received his B.A. in Psychology from the City College 
of the City University of New York in 1967. In 1971, he received his M.A. in 
Clinical Psychology from the University of Iowa under the mentorship of 
Professor Arthur L. Benton, where he also received his Ph.D. in 
PSYCHOLOGY/Neuropsychology in 1972 and was the recipient of an NSF graduate 
student research fellowship. From 1972 to 1973 he received postdoctoral 
training in Neuropsychology with Arthur Benton in the Department of Neurology 
at the University of Iowa. In 1973 and 1974 he completed internships at
the University of Iowa Hospitals and the Illinois Masonic Medical Center in 
Chicago, Illinois, a teaching hospital for the University of Illinois Medical 

Dr. Levin has held faculty appointments at the University of Iowa and the 
Veterans Administration Hospital in Iowa City, Iowa. In 1974 he began an 
almost 20 year tenure at the University of Texas Medical Branch (UTMB) in 
Galveston, culminating in an endowed chair in which he was named Chela
and Jimmy Storm Distinguished Professor in Surgical Research in the Division 
of Neurosurgery, Department of Surgery at UTMB. Dr. Levin left UTMB in 1993 to 
accept a position as Professor in the Department of Surgery, Division of 
Neurosurgery at the University of Maryland Medical System in
Baltimore, Maryland. Dr. Levin is currently Professor and Director of Research 
for the Department of Physical Medicine and Rehabilitation at the Baylor 
College of Medicine in Houston, Texas, where he also has appointments to the 
Department of Pediatrics and the Department of Neurosurgery.

Dr. Levin has received numerous awards, including the NINDS Javits 
Neuroscience Investigator Award, the William F. Caveness Award from the 
National Head Injury Foundation, and the Texas Psychological
Association Award for Outstanding Work in the Field of Traumatic Brain Injury. 
He is also on the editorial boards of several national scientific journals, 
including the Archives of Neurology, Cortex, Neuropsychology, and the Journal 
of the International Neuropsychological Society.

Dr. Paus's interest in the study of brain and behavior in humans began in high 
school when he collected data for his first scientific paper, on vitamin C and 
vigilance. During the subsequent 10 years of medical and Ph.D. studies, Dr. 
Paus has endeavoured to learn more about the mechanisms of cognitive 
processes, such as attention and volition, by using various methods including 
the study of normal development, event-related potentials, the effects of 
frontal-lobe lesions and the examination of psychiatric disorders.

Dr. Paus obtained a Post-doctoral Fellowship to work with Drs. Brenda Milner 
and Michael Petrides during the growth of functional neuroimaging at the MNI. 
Over the past six years he has carried out several blood-flow activation 
studies aimed at elucidating brain mechanisms of volition and attention. In
several collaborative studies he has continued to study patients with brain 
lesions and has extended the exploration of brain mechanisms of arousal into 
other states of consciousness, including sleep and anaesthesia. Dr. Paus has 
embarked on morphometric studies of the cerebral cortex, which became
possible due to advances in magnetic-resonance imaging (MRI) and computational 

Dr. Paus and his colleagues have developed a new technique that allows one to 
study neural connectivity in the living human brain. This technique is based 
on the concurrent use of transcranial magnetic stimulation and positron 
emission tomography. In its first application, they were able to demonstrate 
the pathways connecting the human frontal eye-field with the visual cortex. 
Besides the mapping of neural connectivity of different cortical regions in 
the brain, the technique has strong potential for the study of
the re-mapping of neural pathways following brain injury, or the state of 
functional connectivity in schizophrenia.

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