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glutamate receptor pharmacology

Stacey N. Irizarry irizarry at pantheon.yale.edu
Tue Sep 16 23:28:26 EST 1997

Try SYM2081, a kainate agonist.  They GYKI compound is good stuff but hard
to come by.  Good luck!


Terrence Brannon (brannon at surf.usc.edu) wrote:

: marilee at MED.UNC.EDU (Marilee Shelton) writes:

: > I would like some ideas for antagonists and agonists to separate
: > AMPA-preferring and kainate-preferring receptors.  I am aware of
: > cyclothiazide and concanavalin A to selectively potentiate the responses,
: > but have not had much luck with them.  I need some specific agonists or
: > antagonists.  Also, I have seen a few papers with the AMPA antagonist, GYKI
: > 53655, but I have not found this commercially available.  Does anyone have
: > experience with 1-BCP from Tocris Cookson? Is it very selective?  Any help
: > would be greatly appreciated. 
: > 

: This isnt my specialty, but we did go over a paper yesterday entitled
: "Kainate Receptors Mediate a Slow Postsynaptic Current in Hippocampal
: CA3 Neurons" by Castillo, Malenka and Nicoll in v388: Jul 10 1997 of
: Nature. Page numbers clipped off in my copy :-)

: They talk about something called GYKI which blocks AMPA but not
: kainate receptors and CNQX which blocks both AMPA and kainate. There
: is also some discussion about L-CCG1 which blocks mossy fibre synaptic
: transmission.

: Good luck,
: -- 
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:   Terrence Brannon * brannon at surf.usc.edu * http://quake.usc.edu/~brannon

Stacey Irizarry
irizarry at minerva.cis.yale.edu
WWW: http://pantheon.yale.edu/~irizarry/index.htm

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