Sensory perception (neurobiology query)
hdvorak at cns.caltech.edu
Fri Aug 21 11:46:22 EST 1998
In article <35DC306F.5BF9 at no.spam.thanks.oitunix.oit.umass.edu>,
edh at no.spam.thanks.oitunix.oit.umass.edu says...
>K C Cheng wrote:
>> Re the 1st: action potentials are surely transmitted along dendrites as
>> well. Lots of literature on this. Sorry, I'm too busy etc. right now to
>> find and quote them for you. But try the huge American Physiological
>> Society Handbook, volumes on neurons.
>I think you're confusing action potentials with postsynaptic
>potentials. [rest - accurate but incomplete - snipped]
Action potentials, while usually initiated in the soma or the initial segment
of the axon, can propagate up into the dendrites, thanks to the
voltage-dependent sodium channels found there.
See: Johnston, D., Magee, J.C., Colbert, C.M., and Christie, B.R. Active
properties of neuronal dendrites. Annu. Rev. Neurosci. 19:165-186, 1996,
for a good review of the active properties of dendrites.
Examples of the possible role of back-propagating action potentials in synaptic
Magee, J.C., and Johnston, D. A synaptically controlled, associative signal for
Hebbian plasticity in hippocampal neurons. Science 275:209-213, 1997, and
Markram, H., Lubke, J., Frotscher, M., and Sakmann, B. Regulation of synaptic
efficacy by coincidence of postsynaptic APs and EPSPs. Science 275:213-215,
(Please do not take the use of the term "back-propagating" to mean that this
mechanism could be used to implement back-propagation learning algorithms in
artificial neural networks. This is something different.)
- Hannah Dvorak-Carbone
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