Alpers disease and apoptosis ???
brunhilde.keijers at ping.be
Mon Feb 2 17:31:15 EST 1998
As I'm not medical schooled, I don't fully understand your question I'm
afraid. I think you're talking about EEG-protocols. The only thing I ca=
tell you is there were no "giant potentials" upon lightstimulation. I've
three descriptions of EEG-protocols (in cronological way with one week
intervals, recorded one month after acute onset of the disease) :
1) Lots of delta-activity (2-3 c/s) at background-level (100-200 =B5V) an=
th=E9ta-activity (4-5 c/s) with amplitudo 'till 100 =B5V (symmetrical dif=
2) Th=E9ta-activity (6 c/s) located at the "back" of the brain (100-200 =B5=
with symmetrical pattern; at background-level there is diffuse
delta-activity (2-3 c/s) and th=E9ta-activity (4-6 c/s); no periodical
3) Delta-activity (2-3 c/s) with amplitudo of 60 =B5V and th=E9ta-activit=
c/s) with higer voltages; general "paroxysmes" with high voltage
th=E9ta-activity and multifocal epileptic peaks. =20
I hope you can do something with this.
> Van: Ron Blue <rcb5 at msn.com>
> Aan: Brunhilde Keijers <brunhilde.keijers at ping.be>
> Onderwerp: Re: Alpers disease and apoptosis ???
> Datum: maandag 2 februari 1998 0:27
> Any location to high frequency radio waves?
> Ron Blue
> -----Original Message-----
> From: Brunhilde Keijers <brunhilde.keijers at ping.be>
> To: neur-sci at net.bio.net <neur-sci at net.bio.net>
> Date: Sunday, February 01, 1998 4:21 PM
> Subject: Alpers disease and apoptosis ???
> >Hi everyone,
> >As a biochemical engineer and mother of a son who died of Alpers'
> >(neurodegenerative disease of childhood, spongiform encephalopathy) at
> >age of 16 months, I'm looking for more information about this disease.
> >With our son it wasn't a defect in the mitochondrial DNA, nor were the=
> >liver-abnormalities seen at autopsy.
> >I have been searching for about one year now. I searched in Medline a=
> >visited the website of NORD and many others, but my search has come up
> >very little practical information. As whe will have one chance out of
> >(one says) with a next pregnancy, it is very hard to decide to without
> >possibility of prenatal diagnosis.
> >Is there anyone out there who thinks of Alpers' disease as a fatal
> >deregulation of natural (neuronal) cell death (so called apoptosis)?=20
> >is the chance that there would be for instance a mutation in the Bcl-2
> >Bcl-X-genes (see review article of D.E. Merry and S.J. Korsmeyer in
> >Rev. Neurosci., 1997, 20:245-67)?
> >I also red the article of E.E.Manuelidis et al. (Neurology, 1989,
> >39:615-21) who induced a spongiform encephalopathy in hamsters upon
> >infection with brain-tissue from a 2,5 year old Alpers' disease patien=
> >Are there others who reproduced these (or comparable) experiments ? I=
> >there anyone else who sees a link with prion-diseases ?
> >As I red an interesting abstract of selective binding of cellular prio=
> >protein to Bcl-2 (C. Kurschner and Morgan J.I. in Brain Res. Mol. Brai=
> >Res., 1995, 30(1):165-168), maybe this must be the way to look at prio=
> >diseases and other neurodegenerative diseases, namely receptor-blockin=
> >Bcl-2 by (deformed) prion protein, followed by apoptosis (because of n=
> >feedback-regulation by Bcl-2).
> >Is there anyone in the complicated world of neuroscience who works on
> >neurodegenerative disorders (maybe specific on Alpers' disease) and wh=
> >also thinks it would be interesting for us to sequence one or another
> >involved with apoptosis or prion-diseases ? Please let me know !
> >PS At the moment we are waiting for the results of the sequencing of t=
> >cellular prion protein.
> >I'm looking forward to you reactions !
> >Kind regards from Brunhilde (Belgium)
> >brunhilde.keijers at ping.be
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