Post-Doctoral Position: Role of ion channels in ethanol- and nicotine-dependence

MWN nowakm at musc.edu
Mon Feb 23 14:53:34 EST 1998


Neuroscience Post-Doctoral Position

A post-doctoral position is immediately available for a candidate (MUST
BE A US CITIZEN OR PERMENANT RESIDENT) with a strong background in
electrophysiological recording from mammalian cells, neuronal cultures
and slices (both whole cell and single-channel recording techniques).
Studies will examine the role of nAChRs and other ligand-gated ion
channels in mediating the effects of nicotine and ethanol by employing
viral-mediated gene expression methodologies. These in vitro studies
will provide a foundation for in vivo expression studies using mouse
behavioral models of nicotine- and ethanol-dependence. The overall aim
is to understand how changes in ion channel function at the cellular
level are related to drug-seeking behavior.  Some ongoing projects
include the following:

1)  Effects of chronic nicotine treatment on nAChR expression/function
in mouse hippocampal neuronal cultures.

2)  Effects of ethanol treatment on nAChR expression/function in mouse
hippocampal neuronal cultures.

3)  The effects of prenatal exposure of nicotine and ethanol in mice

4)  The effect of mutiple ethanol withdrawal on NMDA and GABA_A mRNA
levels in mouse models


My laboratory contains a 1) mammalian cell/neuron electrophysiology rig,

2) whole-cell Xenopus oocyte rig, 3) tissue culture facility and 4)
molecular biology facility. The candidate will have the opportunity to
apply his/her existing knowledge of ion channel function in
collaborative projects with researchers employing animal models of
drug-dependence.

My laboratory is located in The Center for Drug and Alcohol Programs
(CDAP) within the Institute of Psychiatry at the Medical University of
South Carolina. CDAP integrates the latest basic and clinical advances
in alcohol and drug abuse research with direct patient care and
education.  Thus, the candidate will have a unique opportunity to
interact with pre-clinical and clinical researchers in the area of
drug-dependence. In
addition, I have a joint appointment in the Department of Cell and
Molecular Pharmacology and Experimental Therapeutics where there is an
emphasis on signal
transduction research.

Candidates should send a CV, names of three references and a brief
statement of research interests to:

Dr. Mark W. Nowak
Room 461N, Institute of Psychiatry
171 Ashley Avenue
Medical University of South Carolina
Charleston, SC 29425

E-mail address: nowakm at musc.edu

MUSC is an equal opportunity employer.







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