Parkinson's disease & rigidiy

Marcello Spinella optimism32 at
Wed Feb 25 23:53:50 EST 1998

Agreed.  It seems that spasticity occurs with either flexors or
extensors, while Parkinsonian rigidity involves excess tone in both
flexors and extensors resulting from the basal ganglia lesion.  While
DOPA or a dopamine agonist corrects this inbalance in the striatum,
baclofen reduces tone by GABA receptors in the spinal grey.  While
baclofen would reduce tone in a Parkinsonian patient, there would still
be antagonistic tone in both flexors and extensors.

Renato Cocchi wrote:

> > From: Marcello Spinella <optimism32 at>
> > Organization: EarthLink Network, Inc.
> > Subject: Parkinson's disease and rigidity
> >
> > If Parkinson's disease involves rigidity, why isn't baclofen
> > effective to treat it?
>  Perhaps  because  Parkinson's rigidity is  a  dopamine-related
> symptom and  baclofen is a B-GABAergic agonist.
>  The  fact  that baclofen is an antispastic  is  insignificant:
> What  seems  the  same symptom can  be  produced  by  different
> breakdowns (eg. haemophilia).
>  Renato Cocchi MD

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