Parkinson's disease & rigidiy
optimism32 at hotmail.com
Wed Feb 25 23:53:25 EST 1998
Agreed. It seems that spasticity occurs with either flexors or
extensors, while Parkinsonian rigidity involves excess tone in both
flexors and extensors resulting from the basal ganglia lesion. While
DOPA or a dopamine agonist corrects this inbalance in the striatum,
baclofen reduces tone by GABA receptors in the spinal grey. While
baclofen would reduce tone in a Parkinsonian patient, there would still
be antagonistic tone in both flexors and extensors.
Renato Cocchi wrote:
> > From: Marcello Spinella <optimism32 at hotmail.com>
> > Organization: EarthLink Network, Inc.
> > Subject: Parkinson's disease and rigidity
> > If Parkinson's disease involves rigidity, why isn't baclofen
> > effective to treat it?
> Perhaps because Parkinson's rigidity is a dopamine-related
> symptom and baclofen is a B-GABAergic agonist.
> The fact that baclofen is an antispastic is insignificant:
> What seems the same symptom can be produced by different
> breakdowns (eg. haemophilia).
> Renato Cocchi MD
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