IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP


Cathy ccarey at mediaone.net
Sun Jul 5 00:43:09 EST 1998

This is my point!

There have been no studies to show the long term adverse effects.

How do you overlook this adverse events and say they are coincidental? I
have over 30 pages of responses. One Mother responded about her 8 year old
son who has fibromyalgia after a vaccine. Imagine an 8 year old boy in this
much pain. Think about it. I am not against vaccines. The standardization
needs to be improved. One life is too many. If it was yours you would think
Check out the following web sites and the article below

 Subject: An Italian Study Finding Biochemical Markers of Vaccine Damage

                                 © 1996, Harris L. Coulter, Ph.D.

Comment by Harris L. Coulter: This is, to my knowledge, the first
investigation to find biochemical markers of
vaccine damage. It has not yet been published but deserves publication. My
translation omits the tables and part of
the bibliography, but the text is complete. This study should also have an
impact on HLA typing, since it shows that
vaccinations can have an effect on the individual's HLA type (i.e., that it
is not necessarily congenital).

Role of Immunogenetics in the Diagnosis of Postvaccinal CNS Pathology

Massimo Montinari*, Biagio Favoino**, and Angela Roberto***
Dept. Of Pediatric Surgery, University of Bari
**Tissue Typing and Organ Transplantation Service, Bari Hospital and
***Virology Outpatient Clinic. Bari Hospital and Polyclinic

Presented in Naples, May 9, 1996, under the auspices of the Associazione
per la Libera Universita Internazionale de
Medicina Omeopatica "Samuel Hahnemann" (LUIMO). Translated from Italian by
Harris L. Coulter, Ph.D.

This study involves observations of 30 patients with post-vaccinal
pathology of the central nervous system and other
systems where the first symptoms appeared concomitantly with, or
immediately after, administration of a vaccine. All
patients were subjected to serologic testing for herpes virus (IgG and IgM)
and to HLA (A, B, C) and HLA-DR-DQ
tissue typing to see if there was any correlation between the emergence of
CNS pathology and these various antigens,
thus to show a possible autoimmune-type immunogenetic basis for
demyelination processes. Statistical comparison
with the Italian population used as controls revealed an increase in the
HLA-A3 and HLA-DR7 antigens. The
presence of A3 and/or DR-7 was observed in 22/30 (73.3%) of the patients.
Key words
Post-vaccinal pathology; HLA system; autoimmune pathology of the CNS.

Post-vaccinal pathology of the central nervous system (CNS) is a topic
deserving further investigation. In fact, our
own experience with 30 patients of Italian nationality, observed between
April, 1994 and October, 1995, shows that
clinical signs of CNS pathology -- associated with dermatitis, food
allergies, constipation, and leaking from the anus --
emerged concomitantly or immediately after vaccination with the Salk or
Sabin polio vaccine, DT, measles, DPT,
anti-tuberculosis, or Hepatitis-B vaccines.

The hypothesis of Herroelen, J. De Keyser, and G. Ebinger on "CNS
demyelination after immunization with
recombinant hepatitis-B vaccine" (Lancet, 338, November 9, 1991,
1174-1175), as verified by A.P. Brezin, M.
Lautier-Frau, M. Hamadani, and O. Rogeaux in their article, "Loss of Vision
and Eosinophilia after Recombinant
Hepatitis-B Vaccine" (Lancet, Italian Edition, April, 1994), suggests the
need for a clinical revaluation and a critical
look at all the patients observed up to now in Italian and European
clinical centers.

The patients examined by us came from various regions of Italy, and all
presented with a clinical history of
convulsions concomitantly with, or immediately after, prophylactic
vaccinations. We excluded from the study all
patients observed by us whose clinical history was not referable to a
vaccination. All the patients were subjected to
tissue typing for HLA (A, B, C) and HLA DR-DQ with the aim of defining the
relative immunogenetic order. The
phenotype was defined by a study of various immune functions: lymphocyte
subpopulations, serum immunoglobulin
content, sphericity of the antibodies to various viruses (CMV, EBV, HSV-1
and HSV-2, VZV).

This allowed us to relate these data to specific clinical pictures --
patients who had earlier been diagnosed with
epilepsy, myoclonic epilepsy, evoving epilepsy, epileptigenic
encephalopathy, autism, West Syndrome, and
Angelman's Syndrome. All the patients had presented with the first symptoms
shortly after receiving the prophylactic
vaccination or somewhat later.
The first symptoms were convulsions, very high fever, or diarrhoea
immediately following a compulsory vaccination.
The parents had told their physicians about this; then, after taking EEGs
and visiting neuropsychiatric specialists or
pediatricians without getting any satisfaction, the physicians had
administered the recall shots of the vaccines leading
very shortly to stabilization of the condition with progressive clinical

These children were mostly from 3 to 9 months old. All patients were
studied for the presence of metabolic diseases
with negative results; then chromosomal mapping was done, also with
negative results; encephalic TAC and RMN
were performed at first appearance of the symptomatology, also with
negative results.

The EEG performed at first appearance of the symptomatology gave a negative
result in 92% of the patients.
Serologic investigations for herpetic virus (IgG and IgM) were positive in
all for IgG and negative for all for IgM,
leading us to estimate seropositivity (IgG) for Epstein-Barr virus of
73.8%, for cytomegalovirus of 71.4%, for Herpes
Simplex virus of 47.6%, and for Varicella-Zoster Virus of 21.4%. In all the
patients we observed diminished
sideremia and a deficit of IgA and IgG with a slight increase of GOT and
GPT. None of the patients had maternally
transmitted viral encephalopathy, and in all the patients the vegetative
and relational life was quite normal prior to
administration of the first dose of vaccine.

The patients were subjected to HLA tissue typing (A, B, and C), and
serologic HLA DR-DQ, with the aim of
checking a possible correlation with the emergence of CNS pathology, and
these antigens indicate a possible
autoimmune immunogenetic basis for the demyelination process. (See A.
Svejgard, P. Platz, and L. P. Ryder in
Immunology Rev. 70, 1983, 193). The chi-square statistical analysis, with
the Italian population as a control (see 11th
International Histocompatibility Workship and Conference, 1992)
demonstrated an increase in the HLA-A3 antigen
(43.3% vs. 25%, P = 0.04, after statistical correction) and the HLA-DR7
antigen (48.3% vs. 24.14% P = 0.007 after
statistical correction). The presence of A3 and/or DR7 was observed in
22/30 (73.3%) of the patients.

Additional cases are under study to better define the possible association
of HLA A3 and/or HLA DR7 with
appearance of this pathology in the CNS following vaccination. HLA system
alleles have an elevated genetic
polymorphism and are inherited as autosomal dominant characteristics. The
combination of the alleles of various loci
in the same chromosomes has been defined as the haplotype or complex gene,
and the complexity of the HLA region
demonstrates, besides the thousand different possible haplotypes, also the
problems: of molecular resemblance (see
G. Laurentaci and B. Favoino, "Immunogenetica e malattie HLA Associate,"
Dedalo Litostampo, Bari, 1991), of
discriminating between self- and non-self-antigens, and of determining the
function of the Class 2a CMI molecules;
any interference with the process of presentation of the antigen can
predispose to an autoimmune disease.
Alterations which do not occur can be due to the action of viral agents
which compromise the specific immune
response because of their resemblance to the "self" tissue antigens. The
consequence is persistence of the infective
agents and a tendency to provoke, through a marked reaction, induction of
an autoimmune disease. This can present
in conditions of marked reactivity to some viruses and to myelin antigens.

A study of the disease associated with genes of the HLA system has shown
that this genetic complex can be
responsible for a particular genetic susceptibility, predisposing to
various diseases characterized predominantly by
immune-system pathogenesis. The observation that many vaccines use
Thimerosal as a preservative, for which we do
not have clear dose-response relationships and whose toxic effects take the
form essentially of neurologic symptoms,
not the least of which are symptoms of the purine pathway of the
innervation of the digestive tube, leads us to
consider that in 66% of cases there was obstinate constipation and in 31%
there was proctic symptomatology with
emission of mucus and blood.

All the patients observed presented various physical problems. The various
types of CNS pathology could be due to a
delatentization of preexisting autoimme damage by viral DNA. It has been
observed that the “cleaner" the species,
from the virologic or microbiologic point of view, the more likely it is to
present autoimmune conditions of the CNS
and other apparatuses. The results indicate that autoimmune pathology is
more frequent in countries where
vaccination is more widespread, i.e., in countries defined as "clean." With
this study, and with the individualization of
alleles such as A3 and DR7, in the presence of viral DNA, it would be
possible to define the subjects at risk of an
autoimmune pathology from vaccination. The action of thimerosal used as an
excipient in vaccines, and whose toxicity
is independent of thedose administered, could demonstrate the possibility
of changes in the aminoacids of the
molecules which preserve the antigen.
This type of study could even be utilized to individualize the
etiopathogenesis of other types of autoimmune pathology.

F. Frank LeFever wrote:

> I'm having trouble with my browser and/or provider: a LONG followup to
> this seems to have disappered into webland.
> Bottom line: I checked PDR and Medline.  NO reason to think ANY kind of
> vaccination causers MS.  Possibility that Hep B vaccination causes
> exacerbation in pre-existing MS--POSSIBILITY.  Medline search for
> health care workers X multiple sclerosis yielded nothing.  Some studies
> directly addressed issue of other kinds of vaccination influencing MS
> course: negative findings.
> My posting of full citationss (in prior attempted reply) may be
> delayed; INS meeting in Budapest...
> LeFever
> In <6net9m$60f at dfw-ixnews4.ix.netcom.com> flefever at ix.netcom.com(F.
> Frank LeFever) writes:
> >
> >In <359A6CA0.75024B0A at mediaone.net> Cathy <ccarey at mediaone.net>
> writes:
> >
> >>
> >>I  was diagnosed with Multiple Sclerosis 2 years ago.
> >>It was brought to my attention recently
> >
> >How? by whom? In what publication?
> >
> > that there is an increase in the
> >>amount of health care workers who have MS.
> >
> >Data? How obtained? where published?
> >
> > They are attributing it to
> >>the Hepatitis B vaccine.
> >
> >Who are "they"?  Some people who have MS?  Somebody who has done a
> >systematic survey with proper statistical analysis?
> >
> >
> >
> > I did have the first shot of the series 2
> >>months before the onset of MS.
> > It is even in the PDR that one of the
> >>adverse reactions can be MS.
> >
> >I will check out the PDR.  Possibly you misread it?  Possibly it said
> >SOME people have SUSPECTED that an EXACERBATION of MS might be one
> >adverse effect???
> >
> >Over the years, MANY things have been SUSPECTED of causing MS--when I
> >first started dealing with MS patients (as a neuropsychologist, not as
> >a physician), over 20 years ago, having small pets in the home was
> >suspected...   Subsequent statistical analysis found the apparent
> >association illusory.
> >
> >>I am just curious as to how many of you have had any kind of a
> >reaction
> >>to any kind of vacccine.
> >
> >ANY reaction to ANY kind of vacciner??? Maybe about 1 in 50?  local
> >soreness, possibly flu-like symptoms, very briefly?
> >
> >
> > Some people with fibromyalgia attribute it to
> >>the Hep B Vaccine.
> >
> >Some may, some attribute it to other things, but without systematic
> >study this is about like attributing thunderstorms to one's having
> >washed the car recently.
> >
> >I'm being a bit sharp or harsh, not because I belittle your concern re
> >MS, but because nut-cases periodically inveigh against vaccinations in
> >general, irresponsibly, when the outcomes of failure to get
> appropriate
> >vaccinations are KNOWN to be deadly.
> >
> >What IS known is that health care workers are at risk for getting Hep
> >B, wwhich is a much more common threat than MS in this group, and
> >faiure to get Hep B vaccination is much more likely to lead to serious
> >illness or death than (so far as has been demonstrated) any risk of
> >"getting" MS (I leave open the question of possible EXACERBATION of
> >pre-existing MS).
> >
> >Do not pass the buck.  Do not refer us to web pages, put up by God
> >knows who.  Wha peer-reviewed studies were cited, and what were the
> >citations?
> >
> >F. Frank LeFever, Ph.D.
> >
> >
> >
> >>The following are address's where you  can find more info. I sure
> >would
> >>appreciate all of your input on this.
> >>http://www.wplg.com/Special%20Reports/HepB.htm
> >>http://www.wplg.com/eoharch/June%2098/eoh0061598.htm
> >>http://WWW.HRSA.DHHS.GOV/bhpr/vicp/new.HTM
> >>http://www.909shot.com/nvicp.htm
> >>http://www.fda.gov/cber/vaers.html
> >>Thanks,
> >>Cathy
> >>
> >>
> >>
> >

-------------- next part --------------
An HTML attachment was scrubbed...
URL: http://iubio.bio.indiana.edu/bionet/mm/neur-sci/attachments/19980705/ff80f61f/attachment.html

More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net