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James P Picotte picotte1 at pilot.msu.edu
Sun Jul 5 23:22:21 EST 1998

I've always understood your point.  There is so much about our immune systems that are still a mystery it doesn't surprise me that in a small percentage of people that vaccines cause some problems and sometimes serious problems.  Whether this is caused ONLY by the vaccine is still very unclear to me.  It is clear that there are some diseases that are associated with certain HLA (Human leukocyte antigens) types in humans.  Certainly cross-reactivity has been observed such as in rheumatic fever and there may be some of this type of reaction involved with vaccines.  Certainly there ARE risks with vaccines, but they are certainly much lower than not using vaccines (I know this is not what your saying).  Of course physicians should be aware of the possibility of some strange result of vaccines even if the vaccine can't be conclusively identified as the etiologic agent in the case.

James P Picotte
Michigan State University
College of Human Medicine
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