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ghb action on the brain?

Anonymous nobody at REPLAY.COM
Wed Jul 8 11:24:02 EST 1998


In an article on ghb (gamma hydroxy butyrate) I read:

   (From the September 10th, 1994 issue of Smart Drug News [v3n6].)

"The Actions of GHB in the Body

   GHB temporarily inhibits the release of dopamine in the brain. This
   may cause increased dopamine storage, and later increased dopamine
   release when the GHB influence wears off [Chin and Kreutzer, 1992].
   This effect could account for the middle-of-the-night wakings common
   with use of higher GHB doses, and the general feelings of increased
   well-being, alertness and arousal the next day."

   The primary disadvantage to GHBs use as a sleep aid is its
   short-term influence; about three hours. During GHBs
   influence, sleep is deeper and more restful, but after the GHB has
   worn off, people have a tendency to wake up. The higher the dose, the
   greater is this tendency. Some have called this pattern the “dawn
   effect” and have speculated that it is related to the release of
   stored-up dopamine. Some people minimize this effect by taking minimal
   doses of GHB. Others take advantage of this effect by getting a couple
   of hours of work done in the middle of the night. Still others choose
   to take a second dose of GHB to sleep for another three hours."

I was wondering how this relates to the body's own sleep mechanism?



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