Apparently IL-1 joins the list of things which will either prevent or
promote IL-1, depending on amount and/or timing.
After many in vitro studies showing preventin of LTP by IL-1, and
behavioral studies which could be interpreted as supporting a
detrimental effect of IL-11 on earning/memory, perhaps at the LTP step,
a recent Proc Nat Acad Sci (USA) report suggests IL-1 in some minimal
amount is NECESSARY for LTP.
In referring to the in vitro and behavioral studies, authors say "most"
used levels of IL-1 far in excess of what might be produced
endogenously except during inflammation. Before I try to track down
all the prior authors and put the question to them, does anybody
reading this have an opinion (preferably based on data) as to levels
used in such studies???
F. Frank LeFever, Ph.D.
New York Neuropsychology Group