IL-1 and LTP

mark mark.haynes at mail.tju.edu
Wed Jul 22 11:29:55 EST 1998


F. Frank LeFever wrote:
> 
> Apparently IL-1 joins the list of things which will either prevent or
> promote IL-1, depending on amount and/or timing.
> 
> After many in vitro studies showing preventin of LTP by IL-1, and
> behavioral studies which could be interpreted as supporting a
> detrimental effect of IL-11 on earning/memory, perhaps at the LTP step,
> a recent Proc Nat Acad Sci (USA) report suggests IL-1 in some minimal
> amount is NECESSARY for LTP.
> 
> In referring to the in vitro and behavioral studies, authors say "most"
> used levels of IL-1 far in excess of what might be produced
> endogenously except during inflammation.  Before I try to track down
> all the prior authors and put the question to them, does anybody
> reading this have an opinion (preferably based on data) as to levels
> used in such studies???
> 
> F. Frank LeFever, Ph.D.
> New York Neuropsychology Group




What were the levels?  I'm guessing that behavioral studies involved in 
vivo admin. so there are complications with other things in serum and etc 
as I'm sure you know.
markH



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