optimism32 at hotmail.com
Mon Mar 23 10:16:26 EST 1998
It makes sense that something held in working memory will be encoded into LTM to
some degree as well, since it probably is salient. My only question to this would
be: can someone without a hippocampus (e.g. H.M.) still perform working memory
tasks? I think the answer is yes, he can hold information on-line for the moment.
Unless he continues to rehearse it or is distrated, the info can be maintained, but
shortly after it rapidly decays. Perhaps the hippocampal role in WM is to carry
the contents of WM in to LTM.
Just a hypothesis
> Have we forgotten that you cannot completely localize function to ONE area of
> the brain?
> Also important... the intricate connections of the hippomcampus AND the
> prefrontal cortex. If you block NMDA receptors of the hippocampus, you disrupt
> working memory (yes, Frank, in an animal model...but think about PCP users;
> Highfield, Nixon, & Amsel, 1996; Behavioral Neuroscience). NMDA receptors are
> involved in a putative molecular model of learning and memory, LTP. Typically,
> when you interfere with LTP, you interfere with memory. Interestingly, LTP
> occurs primarily in the hippocampus and most is NMDA receptor dependent. I
> don't think you can rule out the involvement of the hippocampus with the
> molecular information out there.
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