NMDA receptor antagonists: Isogenic forms?

F. Frank LeFever flefever at ix.netcom.com
Sat Nov 14 23:38:26 EST 1998


Matt--

Nice seeing you at the Society for Neuroscience meeting.  Appreciate
your answer, but didn't he ask about receptor antagonist? i.e. LI-1ra?

Reasonable to suppose variation in IL-1ra, but has this acctually been
studied?

F. Frank LeFever, Ph.D.
New York Neuropsychology Group


In <72ht9l$rri$1 at fremont.ohsu.edu> Matt Jones <jonesmat at ohsu.edu>
writes: 
>
>In article <72f4du$5mt$1 at nnrp1.dejanews.com> , bjk at mblab.gla.ac.uk
writes:
>>Is there any evidence at the moment for isogenic variation of this
receptor?
>
>If by "isogenic" you mean that one gene can produce several different
>types of receptor, then the answer is _yes_. The genes for at least
some
>of the NMDA subunits contain several coding "exons" that are spliced
>together at the RNA stage, so that several different "splice variants"
>can be translated into slightly different proteins. There are about 4
>cassettes that can be mixed and matched in different combinations, so
the
>total number of different gene products possible is considerable.
>
>Matt Jones




More information about the Neur-sci mailing list