Abstrac: Neural division in Brain.

Segundo José Martínez Guzmán segundojm at uned-valencia.net
Mon Nov 16 17:20:26 EST 1998


Dear newsgroup:
    I realized you any of you have problems finding the article about neural
regeneration. Here I enclose you the abstract where you will find the
subject we are talking about. I would like to please youyour  interest about
the subject.

Here you have:
Curr Opin Neurobiol 1998 Oct;8(5):671-676
Discussion point Stem cells of the central nervous system.
Gage FH
Laboratory of Genetics The Salk Institute La Jolla California 92037 USA.
fgage at salk.edu
[Record supplied by publisher]
While criteria for self-renewal and multipotentiality can be met with
varying degrees of confidence on the basis of recent in vitro and in vivo
experiments, a consensus definition of stem cells remains illusive. It has
been demonstrated that adult CNS cells can divide and be induced to
differentiate both in vivo and in vitro. These observations have important
basic and applied implications; however, the true identities of these cells
and factors, as well as the mechanisms that control their fate, are unknown.
PMID: 9811627

And the one I like:
Nat Med 1998 Nov;4(11):1313-7
Neurogenesis in the adult human hippocampus.
Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson
DA, Gage FH
Department of Clinical Neuroscience, Institute of Neurology, Sahlgrenska
University Hospital, Goteborg, Sweden.
[Medline record in process]
The genesis of new cells, including neurons, in the adult human brain has
not yet been demonstrated. This study was undertaken to investigate whether
neurogenesis occurs in the adult human brain, in regions previously
identified as neurogenic in adult rodents and monkeys. Human brain tissue
was obtained postmortem from patients who had been treated with the
thymidine analog, bromodeoxyuridine (BrdU), that labels DNA during the S
phase. Using immunofluorescent labeling for BrdU and for one of the neuronal
markers, NeuN, calbindin or neuron specific enolase (NSE), we demonstrate
that new neurons, as defined by these markers, are generated from dividing
progenitor cells in the dentate gyrus of adult humans. Our results further
indicate that the human hippocampus retains its ability to generate neurons
throughout life.
PMID: 9809557, UI: 99025411






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