krebs research , Dr Kandell

Stephan Anagnostaras stephan at
Thu Nov 26 13:32:17 EST 1998

Yes, he meant CREB, and yes Kandel has started a company to make some
crazy drug - I know a few people who were recruited for this. But as far
as I know they are nowhere near a product, despite all the hype. But who
knows ... :)

In article <73ilac$549 at>, flefever at
Frank LeFever) wrote:

> Bob--
> Is it really possible?  That he heard "CREB" and thought Krebs??  But
> whence "cycle" ?  Maybe he had studied Krebs cycle years ago and was
> thereby primed to hear CREB as kreb???  Possible.  But I find it hard
> to believe that Kandel would have said he intended to market a pill in
> 10 years (or ever).   And yet, and yet... Columbia has invested a lot
> in its new biotech/commercial facilities (where Malcom X was shot)...
> (Did you really see this program, or is this just an inspired guess?)
> F. Frank LeFever, Ph.D.
> New York Neuropsychology Group
> In <73h39k$atl$1 at>
> mihalek at (Robert M. Mihalek) writes: 
> >
> >In article <365B5480.3A47 at>
> >Mike <roboart at> writes:
> >
> >> I saw a show on the Discovery Channel last week (Nov 15-Nov 20)
> about
> >> memory.  
> >> It had a article on a doctor named "kandell" (not sure about
> spelling)
> >> who was doing reseach on the krebs cycle in rodents.  Apparently he
> was
> >> having success in helping older rats improve their memory by using a
> >> substance(drug) he developed.  It was said that he intends to market
> the
> >> substance as a pill in the next 10 years.
> >> Also in a seperate part of the same show was a article about a man
> named
> >> HM who had amnesia for the past 30-40 years after a surgery.
> >
> >Dr. Eric Kandel at Columbia University in New York City is the man.
> The
> >research in question is about a class of proteins called cyclic AMP
> >response-element binding proteins: CREB. These proteins have been show
> >to activate gene transcription in vertebrates and invertebrates
> >following specific types of training procedures designed to induce
> >long-term memory formation.
> >
> >
> >Bob Mihalek, Ph.D.
> >University of Pittsburgh School of Medicine
> >Department of Anesthesiology/CCM
> >

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