CREB-poor rodents

F. Frank LeFever flefever at ix.netcom.com
Mon Nov 30 00:06:56 EST 1998



At last, amidst all the nonsense (from loonely genius martyrs) (I meant
to write "lonely", but accidentally validated Freud...)--SOME ACTUAL 
NEUROSCIENCE INFO and useful references!  THANK YOU!

F. LeFever


In <stephan-2911981716380001 at we-24-130-9-218.we.mediaone.net>
stephan at nospam.ucla.edu (Stephan Anagnostaras) writes: 
>
>In article <73qeta$lj8 at dfw-ixnews4.ix.netcom.com>,
>flefever at ix.netcom.com(F. Frank LeFever) wrote:
>
>> Even a clock that is no longer running will be exactly right twice a
>> day.
>> 
>>   Apparently kkollins is correct: the program does seem to have
>> included a segment on Eric Kandel's work (as well as another
segment,
>> on the famous patient HM; I mention this because kkollins clipped
this
>> from the original post, leaving the rest of my comment mysterious to
>> those who did not see it).
>> 
>> I say apparently, because I have not seen a response from anyone
>> explicitly saying that he saw the program and can verify this; but
the
>> surmise (by another respondent) that what was heard as "kreb" was
>> actually CREB seems reasonable. 
>> 
>> For kkollins not to comment on the unlikelihood that Eric Kandel
would
>> be talking about the Krebs cycle in rodents, however, suggests that
his
>> knowledge of Kandel's work is nil, and he is just one of thousands
>> millions?) who have heard or seen Kandel's name over the past 2-3
>> decades.  
>> 
>> re-shaping memory so that CREB comes out as Krebs cycle is
>> understandable, but what about "in rodents"?  Possibly Kandel did
speak
>> of his more recent mouse work, but maybe Aplysia was translated as
"sea
>> hare" and the listener/viewer heard "hare", thought hares were still
>> classified as rodents, and therefore---!
>> 
>> Of the 12 posters with Kandel's name somewhere among the authors (at
>> Society for Neuroscience a few weeks ago), only one of the Aplysia
>> abstracts included a reference to CREB (none of the mouse abstracts
>> did); CREB references in recent articles (4 yrs) in Medline were all
in
>> Aplysia papers, except one mouse paper looking at something
"downstream
>> from CREB-1".  However, "CREB in rodents" may have been cited in
that
>> program--did anybody see it? (i.e. any accurate reporters?)
>> 
>> re my remarks about kkollins' willingness to speak on matters he
>> scarcely understands: please apply them to more appropriate
occasions
>> past and future...
>> 
>> F. Frank LeFever, Ph.D.
>> New York Neuropsychology Group
>
>Sure, the reason you didn't find it is because the CREB stuff in the
mouse
>wasn't done by Kandel it was done in Alcino Silva's lab (who I work
for).
>The CREB mutant mouse (a mouse for which two of the major CREB
isoforms
>have been knocked out) has a profound phenotype... it learns just
about
>everything fine and then forgets it an hour or so later... it shows a
>similar pattern in synaptic plasticity.  The CREB mechanism is
conserved
>at least in drosophila, aplysia, and mice (and several others), so it
is
>likely to work in humans. The problems of trying to make a drug out of
it
>are profound, I won't go into this; if it does work, it will take many
>years to make it work.
>
>Anyway try reading:
>
>Silva et al. CREB and Memory. Annu Rev Neurosci. 1998;21:127-48.
>
>Kogan et al. Spaced training induces normal long-term memory in 
>CREB mutant mice.Curr Biol. 1997 Jan 1;7(1):1-11. 
>
>Bourtchuladze et al. Deficient long-term memory in mice with a
targeted
>mutation of the cAMP-responsive element-binding protein. Cell. 1994
Oct
>7;79(1):59-68




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