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long term potentiation

Hemidactylus at my-dejanews.com Hemidactylus at my-dejanews.com
Sun Oct 11 19:14:18 EST 1998

On my journey through the vast LTP literature in the library, I managed to
find some decent articles. I'm still not clear on the possible relationships
of Alzheimer's disease and LTP, but on a Medline search I found several
articles, one of which I had immediate access to. The article (Nalbantoglu et
al, 1997) discusses research using transgenic mice with a segment of amyloid
precursor protein (APP) incorporated into their genome. These mice had LTP
maintenance deficits. I wonder what inferences about the relation of LTP and
AD in humans can be made. I need to hunt down similar studies in order to get
a better grasp of this issue.

Among the many studies I managed to find, a review by Bliss and Collingridge
(1993) seems to have the best overview of LTP and its complexity. The other
studies I've obtained are issue specific.


Bliss TVP and Collingridge GL. 1993. A synaptic model of memory: long-term
potentiation in the hippocampus. Nature (361): 31-9

Nalbantoglu J, Tirado-Santiago G, Lahsaini A, et al. 1997. Impaired learning
and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid
precursor protein. Nature (387): 500-5

Scott Chase (note followups at anthym at webtv.net)

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