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Serotonin and Depression

Dag Stenberg stenberg at cc.helsinki.fi
Wed Oct 14 03:01:31 EST 1998


kkollins at pop3.concentric.net wrote:
> But, through the diligent efforts of the experimentalists,
> the Neuroscience stacks have been overfolowing with more than enough proven
> information for decades to allow everything to be cross-correlated at a
> verifiably-lasting foundation level. 

Just another comment about that. The information from "decades" is partly
irrelevant because of the development of newer methods. This is something we
see regularly: some new approach represents a breakthrough and makes a bunch
of old data and conclusions obsolete. One example could be molecular
biological methods - actually measuring gene expression in situ, gene
regulation, doing transgenics. Another example might be the impact of in
vivo microdialysis or in situ electrochemistry - putting a probe into a
specific location and measuring neurochemical changes there (as opposed to
indirect measurements from faraway places like blood, urine or cerebrospinal
fluid), possible in combination with neuronal activity recordings. With new
methods, one finds things that could not possible be measured before. In my
own field, for instance, the relation of serotonin to sleep was
misunderstood until this type of measurements were possible. 

Dag Stenberg



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