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F. Frank LeFever flefever at ix.netcom.com
Fri Oct 16 23:41:47 EST 1998

Sorry that I don't have info you need.  However, I need YOUR info: can
you tell me more about anoxia inducing LTP?  Do you have references to
published reports?  Just a guess: anoxia and many other brain insults
can initiate intense excitotoxic (excitatory amino acid) reactions; at
a given moment, NMDA activation and NO amplification might be just at
the level to induce LTP. (outside this window of opportunity, I think
it would block LTP--see Izumi & Zorumski)

(If publication is in Russian,, OK; I can read NYEMNOGA...and I have
Russian friends.)

F. Frank LeFever, Ph.D.
New York Neuropsychology Group

In <36274082.8C9B9C74 at venus.iteb.serpukhov.su> Alexey Semyanov
<semyanov at venus.iteb.serpukhov.su> writes: 
>Short-term potassium increase is known to lead long-lasting increase
>synaptic efficiency. According to our own data it can lead EPSP-spike
>potentiation in CA1 hippocampal slices. On other hand there are some
>experimental evidences that brief anoxic episode can induce LTP also.
>It seems to be due to potassium increase during anoxia.
>Unfortunately, when I attempt to test it changing solution with gas
>mixture O2+CO2 to solution with N2+CO2 I was not successful. I haven’t
>seen any depression of responses during 30 min !!!
>The volume of my recording chamber is about 2 ml; it is open for air.
>The speed of superfusion is 2.5 ml/min. I think this problem is
>of wrong chamber construction. Could anybody suggest me something
>this situation? I will be very grateful for suitable references or
>design of such chamber with a description.

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