F. Frank LeFever flefever at
Wed Oct 21 00:12:03 EST 1998

A few years after I was born (in a little house on the prairie), I had
tonsils removed under ether anesthesia, but recall only the night in
the hotel (n.b.: not hospital) afterwards.  A couple of years after
this, a repeat tonsillectomy, and I recall induction (ether dripping on
a gauze cone? by nurse/receptionist?) only vaguely,but unpleasant; I
vividly recall the ether dream, residual complaint of nausea
(nurse/receptionist amused by such a little boy saying "OK, but my
stomach is a little nauseated").  I think pungent odor as well as total
experience more unpleasant for a macrosmic animal such as a rat.

Dislocation of neck AFTER perfusion?  a bit redundant? ("overkill"?)
When the returning fluid begins to run clear, isn't it pretty much all
over?  If not, wouldn't the first jolt of formalin do it?

F. LeFever

In <70id1k$5ps$3 at> Sturla Molden <stumol at>
>Jose Andrade <jandrade at> wrote:
>: I would like to know your opinion concerning the anesthesia with
>: followed by transcardiac perfusion of lab rats .
>Ether anastesia is not used on humans behacuse 
>the indcution is considered extremely
>painful and unplesant. There is no reason to
>believe that rats feel any different about the
>matter. I have not tried ether myself, but I
>when I was a child (back in the seventies) I was
>on several occcations given halothane anastesia.
>I have never suffocted, but I do not think the
>feeling from inhalation of halothane is much worse
>than suffoction. And if it is true that ether 
>is even worse, my advice would be to avoid 
>the practice. 
>I suggest you use an intraperitoneal injection
>of pentobarbitone/chloral hydrate mixture or 
>a subcutaneous injection of hypnorm/dormicum 
>mixture imstead? When the rat is fully anaestisied 
>you can give is an intracardical perfusion and 
>kill it by a rapid dislocation of the neck.
>Sturla Molden

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