IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP

Can a human being remember pain ?

Richard M Wagers cortical at earthlink.net
Sun Oct 25 11:04:06 EST 1998

In addition to Frank LeFever's suggestions, you might also look into:

-spinal wind-up

-central dyasthesia


F. Frank LeFever wrote:

> Katrina--
> We all share your dismay and resentment; this newsgroup has become an
> outlet for some bizarre and embarassing, undisciplined and
> self-indulgent or perhaps pathological thinking.
> Some lines of research to look into:
> "Phantom limb" studies.
> "Chronic pain" or "central pain" studies.
> I have paid someowhat more attention to the second line.  There are
> some complex sequences of events, involving substance P, IL-1, NO,
> glutamate, and NMDA, by which peripheral stimuli can induce central
> changes (peripheral, i.e. nerves outside spinal cord; central, in the
> spinal cord or higher) which are long-lasting or perhaps permanent.
> The glutamate/NMDA aspect is very similar to what in the brain is a
> route to LTP, a popular "model" of memory formation.
> In one paradigm, a local irritation by formalin can produce changes
> such that there is a general (i.e. not local or regional) allodynia or
> abnormal sensitivity to painful stimuli.
> F. Frank LeFever, Ph.D.
> New York Neuropsychology Group

More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net