Thank you, both of you. I'll get studying; the question relates to a
potential character in a novel I'll be working on soon. I've met people with
some bizarre (and tragic) after effects of burns in particular; I've always
wondered about it.
Richard M Wagers wrote in message <36334BF5.C578E6BA at earthlink.net>...
>In addition to Frank LeFever's suggestions, you might also look into:
>F. Frank LeFever wrote:
>>>> We all share your dismay and resentment; this newsgroup has become an
>> outlet for some bizarre and embarassing, undisciplined and
>> self-indulgent or perhaps pathological thinking.
>>>> Some lines of research to look into:
>>>> "Phantom limb" studies.
>>>> "Chronic pain" or "central pain" studies.
>>>> I have paid someowhat more attention to the second line. There are
>> some complex sequences of events, involving substance P, IL-1, NO,
>> glutamate, and NMDA, by which peripheral stimuli can induce central
>> changes (peripheral, i.e. nerves outside spinal cord; central, in the
>> spinal cord or higher) which are long-lasting or perhaps permanent.
>>>> The glutamate/NMDA aspect is very similar to what in the brain is a
>> route to LTP, a popular "model" of memory formation.
>>>> In one paradigm, a local irritation by formalin can produce changes
>> such that there is a general (i.e. not local or regional) allodynia or
>> abnormal sensitivity to painful stimuli.
>>>> F. Frank LeFever, Ph.D.
>> New York Neuropsychology Group